Showing pharmacokinetics for (-)-Epicatechin metabolite after consumption of Cocoa, powder in rats Metabolism

Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J Agric Food Chem 49:6050-6 PubMed (25829765)

Plasma analysed after enzymatic deconjugation

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Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 4 8 18
1 150 mg/kg bw Single Dose 0 0.35 0.17 0.04 0 0
cocoa powder
2 750 mg/kg bw Single Dose 0 2.12 1.2 0.4 0 0
cocoa powder
3 1500 mg/kg bw Single Dose 0 5.08 3.76 1.76 0.21 0.02
cocoa powder
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0,8.0,18.0|0.0,0.35,0.17,0.04,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,2.12,1.2,0.4,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,5.08,3.76,1.76,0.21,0