Showing pharmacokinetics for (-)-Epicatechin metabolite after consumption of various sources

Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J Agric Food Chem 49:6050-6 PubMed (25829765)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number	Dose	Multiple Dose Duration	Time (hours)						Polyphenol Source Name as described in publication
			0	1	2	4	8	18
1	1 mg/kg bw	Single Dose	0	0.97	0.67	0.31	0	0	(-)-epicatechin
2	5 mg/kg bw	Single Dose	0	3.21	2.04	1	0.21	0.2	(-)-epicatechin
3	10 mg/kg bw	Single Dose	0	4.41	2.84	1.09	0.15	0	(-)-epicatechin
4	150 mg/kg bw	Single Dose	0	0.35	0.17	0.04	0	0	cocoa powder
5	750 mg/kg bw	Single Dose	0	2.12	1.2	0.4	0	0	cocoa powder
6	1500 mg/kg bw	Single Dose	0	5.08	3.76	1.76	0.21	0.02	cocoa powder

L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0,8.0,18.0|0.0,0.97,0.67,0.31,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,3.21,2.04,1.0,0.21,0.2|0.0,1.0,2.0,4.0,8.0,18.0|0.0,4.41,2.84,1.09,0.15,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,0.35,0.17,0.04,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,2.12,1.2,0.4,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,5.08,3.76,1.76,0.21,0

Showing pharmacokinetics for (-)-Epicatechin metabolite after consumption of various sources Metabolism

Plasma analysed after enzymatic deconjugation