Showing pharmacokinetics for 3'-O-Methylepicatechin metabolite after consumption of Cocoa, powder in rats Metabolism

Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J Agric Food Chem 49:6050-6 PubMed (25829765)

Plasma analysed after enzymatic deconjugation

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Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 4 8 18
1 150 mg/kg bw Single Dose 0 0.12 0.03 0.02 0 0
cocoa powder
2 750 mg/kg bw Single Dose 0 1.05 0.77 0.38 0.47 0
cocoa powder
3 1500 mg/kg bw Single Dose 0 2.49 2.35 1.6 0.69 0
cocoa powder
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0,8.0,18.0|0.0,0.12,0.03,0.02,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,1.05,0.77,0.38,0.47,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,2.49,2.35,1.6,0.69,0