Showing pharmacokinetics for 3'-O-Methylepicatechin metabolite after consumption of various sources

Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J Agric Food Chem 49:6050-6 PubMed (25829765)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number	Dose	Multiple Dose Duration	Time (hours)						Polyphenol Source Name as described in publication
			0	1	2	4	8	18
1	1 mg/kg bw	Single Dose	0	1	0.74	0.73	0.3	0	(-)-epicatechin
2	5 mg/kg bw	Single Dose	0	3.05	2.32	1.92	1.04	0	(-)-epicatechin
3	10 mg/kg bw	Single Dose	0	4.5	3.51	1.83	0.7	0.03	(-)-epicatechin
4	150 mg/kg bw	Single Dose	0	0.12	0.03	0.02	0	0	cocoa powder
5	750 mg/kg bw	Single Dose	0	1.05	0.77	0.38	0.47	0	cocoa powder
6	1500 mg/kg bw	Single Dose	0	2.49	2.35	1.6	0.69	0	cocoa powder

L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0,8.0,18.0|0.0,1.0,0.74,0.73,0.3,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,3.05,2.32,1.92,1.04,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,4.5,3.51,1.83,0.7,0.03|0.0,1.0,2.0,4.0,8.0,18.0|0.0,0.12,0.03,0.02,0.0,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,1.05,0.77,0.38,0.47,0.0|0.0,1.0,2.0,4.0,8.0,18.0|0.0,2.49,2.35,1.6,0.69,0

Showing pharmacokinetics for 3'-O-Methylepicatechin metabolite after consumption of various sources Metabolism

Plasma analysed after enzymatic deconjugation