Showing pharmacokinetics for 4-O-Methylgallic acid metabolite after consumption of Grape, seed, polyphenol extract in rats

Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J Alzheimers Dis 18:113-24 PubMed (19625746)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (ng/mL)
Number	Dose	Multiple Dose Duration	Time (hours)						Polyphenol Source Name as described in publication
			0	0.5	1	2	4	8
1	50 mg/kg bw	Single Dose	0	25	40	20	0	0	grape seed polyphenolic extract
2	100 mg/kg bw	Single Dose	0	50	55	50	0	0	grape seed polyphenolic extract
3	150 mg/kg bw	Single Dose	0	75	60	50	0	0	grape seed polyphenolic extract

Ml)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,4.0,8.0|0.0,25.0,40.0,20.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,50.0,55.0,50.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,75.0,60.0,50.0,0.0,0

Showing pharmacokinetics for 4-O-Methylgallic acid metabolite after consumption of Grape, seed, polyphenol extract in rats Metabolism

Plasma analysed after enzymatic deconjugation