Showing pharmacokinetics for Gallic acid metabolite after consumption of Grape, seed, polyphenol extract in rats Metabolism

Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J Alzheimers Dis 18:113-24 PubMed (19625746)

Plasma analysed after enzymatic deconjugation

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Plasma Concentration (ng/mL)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 0.5 1 2 4 8
1 50 mg/kg bw Single Dose 0 150 100 90 0 0
grape seed polyphenolic extract
2 100 mg/kg bw Single Dose 0 110 200 200 50 0
grape seed polyphenolic extract
3 150 mg/kg bw Single Dose 0 300 200 150 50 0
grape seed polyphenolic extract
Ml)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,4.0,8.0|0.0,150.0,100.0,90.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,110.0,200.0,200.0,50.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,300.0,200.0,150.0,50.0,0