Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J Alzheimers Dis 18:113-24 PubMed (19625746)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (ng/mL)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 0.5 1 2 4 8
1 50 mg/kg bw Single Dose 0 150 100 90 0 0
Gallic acid
2 50 mg/kg bw Single Dose 0 25 40 20 0 0
4-O-Methylgallic acid
3 50 mg/kg bw Single Dose 0 100 100 50 0 0
(+)-Catechin
4 50 mg/kg bw Single Dose 0 0 15 0 0 0
3'-O-Methylcatechin
5 50 mg/kg bw Single Dose 0 100 150 75 0 0
(-)-Epicatechin
6 50 mg/kg bw Single Dose 0 0 15 0 0 0
3'-O-Methylepicatechin
Ml)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,4.0,8.0|0.0,150.0,100.0,90.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,25.0,40.0,20.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,100.0,100.0,50.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,0.0,15.0,0.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,100.0,150.0,75.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,0.0,15.0,0.0,0.0,0