Showing pharmacokinetics for metabolites after consumption of Grape, seed, polyphenol extract in rats Metabolism
Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J Alzheimers Dis 18:113-24 PubMed (19625746)
Plasma analysed after enzymatic deconjugation
| Plasma Concentration (ng/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||||
| 0 | 0.5 | 1 | 2 | 4 | 8 | |||||
| 1 | 50 mg/kg bw | Single Dose | 0 | 150 | 100 | 90 | 0 | 0 |
Gallic acid
|
|
| 2 | 50 mg/kg bw | Single Dose | 0 | 25 | 40 | 20 | 0 | 0 |
4-O-Methylgallic acid
|
|
| 3 | 50 mg/kg bw | Single Dose | 0 | 100 | 100 | 50 | 0 | 0 |
(+)-Catechin
|
|
| 4 | 50 mg/kg bw | Single Dose | 0 | 0 | 15 | 0 | 0 | 0 |
3'-O-Methylcatechin
|
|
| 5 | 50 mg/kg bw | Single Dose | 0 | 100 | 150 | 75 | 0 | 0 |
(-)-Epicatechin
|
|
| 6 | 50 mg/kg bw | Single Dose | 0 | 0 | 15 | 0 | 0 | 0 |
3'-O-Methylepicatechin
|
|