Showing pharmacokinetics for 3'-O-Methylepicatechin metabolite after consumption of Grape, seed, polyphenol extract in rats Metabolism

Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J Alzheimers Dis 18:113-24 PubMed (19625746)

Plasma analysed after enzymatic deconjugation

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Plasma Concentration (ng/mL)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 0.5 1 2 4 8
1 50 mg/kg bw Single Dose 0 0 15 0 0 0
grape seed polyphenolic extract
2 100 mg/kg bw Single Dose 0 40 60 40 0 0
grape seed polyphenolic extract
3 150 mg/kg bw Single Dose 0 70 125 130 100 50
grape seed polyphenolic extract
Ml)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,4.0,8.0|0.0,0.0,15.0,0.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,40.0,60.0,40.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,70.0,125.0,130.0,100.0,50