Showing pharmacokinetics for (-)-Epicatechin metabolite after consumption of Grape, seed, polyphenol extract in rats Metabolism

Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease. J Alzheimers Dis 18:113-24 PubMed (19625746)

Plasma analysed after enzymatic deconjugation

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Plasma Concentration (ng/mL)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 0.5 1 2 4 8
1 50 mg/kg bw Single Dose 0 100 150 75 0 0
grape seed polyphenolic extract
2 100 mg/kg bw Single Dose 0 300 375 300 0 0
grape seed polyphenolic extract
3 150 mg/kg bw Single Dose 0 725 750 725 25 0
grape seed polyphenolic extract
Ml)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,4.0,8.0|0.0,100.0,150.0,75.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,300.0,375.0,300.0,0.0,0.0|0.0,0.5,1.0,2.0,4.0,8.0|0.0,725.0,750.0,725.0,25.0,0