Matsumoto H., Ikoma Y., Sugiura M., Yano M., Hasegawa Y. (2004) Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma. J Agric Food Chem 52:6653-9 PubMed (15479036)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 4 8 12 15
1 50 mg/kg bw Single Dose 0 0.22 0.26 0.15 0.01
Homoeriodictyol
2 50 mg/kg bw Single Dose 0 0.6 0.25 0.15 0.1
Hesperetin
L)&chxp=1,50|3,50&chd=t:0.0,4.0,8.0,12.0,15.0|0.0,0.22,0.26,0.15,0.01|0.0,4.0,8.0,12.0,15.0|0.0,0.6,0.25,0.15,0