Showing pharmacokinetics for Isorhamnetin metabolite after consumption of various sources Metabolism

Lan K., Jiang X., He J. (2007) Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokin. Rapid Commun Mass Spectrom 21:112-20

Plasma analysed after enzymatic deconjugation

Plasma Concentration (ng/mL)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1.5 4 10 24 60
1 0.25 mg/kg bw Single Dose 0 11 32 44 23 2
isorhamnetin
2 0.5 mg/kg bw Single Dose 0 20 49 39 24 3
isorhamnetin
3 1 mg/kg bw Single Dose 0 26 31 54 31 9
isorhamnetin
Ml)&chxp=1,50|3,50&chd=t:0.0,1.5,4.0,10.0,24.0,60.0|0.0,11.0,32.0,44.0,23.0,2.0|0.0,1.5,4.0,10.0,24.0,60.0|0.0,20.0,49.0,39.0,24.0,3.0|0.0,1.5,4.0,10.0,24.0,60.0|0.0,26.0,31.0,54.0,31.0,9