Showing pharmacokinetics for 3-O-Methylrosmarinic acid metabolite after consumption of Rosmarinic acid in rats Metabolism
Baba S., Osakabe N., Natsume M., Terao J. (2004) Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric aci. Life Sci 75:165-78 PubMed (15120569)
Plasma analysed after enzymatic deconjugation
| Plasma Concentration (µmol/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) |
Polyphenol Source Name as described in publication |
|||||
| 0 | 0.5 | 1 | 2 | 5 | 12 | ||||
| 1 | 50 mg/kg bw | Single Dose | 0 | 0.4 | 0.5 | 0.3 | 0.2 | 0 |
rosmarinic acid in deoinized water
|