Suarez M., Romero M.P., Macia A., Valls R.M., Fernandez S., Sola R., Motilva M.J. (2009) Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography-tandem mass sp. J Chromatogr B Analyt Technol Biomed Life Sci 877:4097-106

Plasma analysed without enzymatic deconjugation

Plasma Concentration (┬Ámol/L)
Number Dose Multiple Dose Duration Time (minutes) Metabolite
0 60 120
1 30 mL Single Dose 0 0 7.55
Tyrosol 4-sulfate
2 30 mL Single Dose 0 0 0.03
Hydroxytyrosol
3 30 mL Single Dose 0 1.24 0.11
Homovanillic acid 4-sulfate
4 30 mL Single Dose 0 25.14 4.66
Vanillin 4-sulfate
5 30 mL Single Dose 0 0.05 0.04
Vanillic acid 4-sulfate
6 30 mL Single Dose 0 0 0.31
3,4-DHPEA-EDA
7 30 mL Single Dose 0 0 0.01
p-HPEA-EDA
8 30 mL Single Dose 0 0.74 1.02
Vanillin
9 30 mL Single Dose 0 3.26 0
Vanillic acid
10 30 mL Single Dose 0 6.32 3.53
4-Hydroxybenzoic acid
L)&chxp=1,50|3,50&chd=t:0.0,60.0,120.0|0.0,0.0,7.55|0.0,60.0,120.0|0.0,0.0,0.03|0.0,60.0,120.0|0.0,1.24,0.11|0.0,60.0,120.0|0.0,25.14,4.66|0.0,60.0,120.0|0.0,0.05,0.04|0.0,60.0,120.0|0.0,0.0,0.31|0.0,60.0,120.0|0.0,0.0,0.01|0.0,60.0,120.0|0.0,0.74,1.02|0.0,60.0,120.0|0.0,3.26,0.0|0.0,60.0,120.0|0.0,6.32,3