Showing all polyphenol metabolites originating from consumption of Grapefruit, juice Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Caffeic acid |
Food administered |
430 mL | Single dose | 9 | 0.4 µmol after 12 hours | ITO 2005 | ||||||
| Enterodiol |
Food administered |
430 mL | Single dose | 9 | 0 µmol after 12 hours | ITO 2005 | ||||||
| Enterolactone |
Food administered |
430 mL | Single dose | 9 | 1.4 µmol after 12 hours | ITO 2005 | ||||||
| Isorhamnetin |
Food administered |
430 mL | Single dose | 9 | 0.1 µmol after 12 hours | ITO 2005 | ||||||
| m-Coumaric acid |
Food administered |
430 mL | Single dose | 9 | 0.3 µmol after 12 hours | ITO 2005 | ||||||
| Naringenin |
Food administered |
430 mL | Single dose | 9 | 24.7 µmol after 12 hours | ITO 2005 | ||||||
| Phloretin |
Food administered |
430 mL | Single dose | 9 | 5 µmol after 12 hours | ITO 2005 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Naringenin 4'-O-glucuronide |
Food administered |
900 mL | Single dose | 1 | Detected (unquantified) | DAVIS 2006 | ||||||
| Naringenin 7-O-glucuronide |
Food administered |
900 mL | Single dose | 1 | Detected (unquantified) | DAVIS 2006 | ||||||