Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
(-)-Epigallocatechin 3-O-gallate Not applicable 2 mg/kg bw Single dose 4 2 0.09 2.5 236.6 MENG 2002
200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
1,3,5-Trimethoxybenzene Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
3-O-Methylgallic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
3-Phenylpropionic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
4''-O-Methylepigallocatechin 3-O-gallate Not applicable 2 mg/kg bw Single dose 4 Trace amount Trace amount MENG 2002
4',4"-O-Dimethylepigallocatechin 3-O-gallate Not applicable 2 mg/kg bw Single dose 4 2 0.01 2.8 46.9 MENG 2002
4-Ethylbenzoic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
4-Ethylphenol Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
4-O-Methylgallic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
5-(3',4',-dihydroxyphenyl)-γ-valerolactone Not applicable 200 mg Single dose 4 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 MENG 2002
5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone Not applicable 200 mg Single dose 4 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 MENG 2002
5-(3',5'-dihydroxyphenyl)-γ-valerolactone Not applicable 200 mg Single dose 4 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 MENG 2002
Benzoic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Dihydro-p-coumaric acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Dihydrocaffeic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Ferulic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Gallic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Methoxyphenylacetic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Protocatechuic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Vanillic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
mouse studies
(-)-Epigallocatechin 3-O-gallate Not applicable 0.3 % of ad libitum drinking fluid 0 5 Detected (unquantified) 90.6 after 3 days MENG 2002
4',4"-O-Dimethylepigallocatechin 3-O-gallate Not applicable 0.3 % of ad libitum drinking fluid 0 5 Detected (unquantified) 36.7 after 3 days MENG 2002
5-(3',4',-dihydroxyphenyl)-γ-valerolactone Not applicable 0.3 % of ad libitum drinking fluid 0 5 Trace amount MENG 2002
5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone Not applicable 0.3 % of ad libitum drinking fluid 0 5 Trace amount MENG 2002
5-(3',5'-dihydroxyphenyl)-γ-valerolactone Not applicable 0.3 % of ad libitum drinking fluid 0 5 Detected (unquantified) MENG 2002
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
mouse studies
Epigallocatechin 3-O-gallate-7-O-glucoside-4''-O-glucuronide Not applicable 200 mg/kg bw Single dose 4 Detected (unquantified) SANG 2008_02