Showing all polyphenol metabolites originating from consumption of dietary polyphenol (-)-Epigallocatechin 3-O-gallate Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| (-)-Epigallocatechin 3-O-gallate | Not applicable | 2 mg/kg bw | Single dose | 4 | 2 | 0.09 | 2.5 | 236.6 | MENG 2002 | |||
| 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||||
| 1,3,5-Trimethoxybenzene | Not applicable | 200 mg | Single dose | 12 |
|
|
LOKE 2009 | |||||
| 3-O-Methylgallic acid | Not applicable | 200 mg | Single dose | 12 |
|
|
LOKE 2009 | |||||
| 3-Phenylpropionic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| 4''-O-Methylepigallocatechin 3-O-gallate | Not applicable | 2 mg/kg bw | Single dose | 4 | Trace amount | Trace amount | MENG 2002 | |||||
| 4',4"-O-Dimethylepigallocatechin 3-O-gallate | Not applicable | 2 mg/kg bw | Single dose | 4 | 2 | 0.01 | 2.8 | 46.9 | MENG 2002 | |||
| 4-Ethylbenzoic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| 4-Ethylphenol | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| 4-O-Methylgallic acid | Not applicable | 200 mg | Single dose | 12 |
|
|
LOKE 2009 | |||||
| 5-(3',4',-dihydroxyphenyl)-γ-valerolactone | Not applicable | 200 mg | Single dose | 4 |
|
MENG 2002 | ||||||
| 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone | Not applicable | 200 mg | Single dose | 4 |
|
MENG 2002 | ||||||
| 5-(3',5'-dihydroxyphenyl)-γ-valerolactone | Not applicable | 200 mg | Single dose | 4 |
|
MENG 2002 | ||||||
| Benzoic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| Dihydro-p-coumaric acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| Dihydrocaffeic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| Ferulic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| Gallic acid | Not applicable | 200 mg | Single dose | 12 |
|
|
LOKE 2009 | |||||
| Methoxyphenylacetic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| Protocatechuic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| Vanillic acid | Not applicable | 200 mg | Single dose | 12 |
|
LOKE 2009 | ||||||
| mouse studies | ||||||||||||
| (-)-Epigallocatechin 3-O-gallate | Not applicable | 0.3 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | 90.6 after 3 days | MENG 2002 | |||||
| 4',4"-O-Dimethylepigallocatechin 3-O-gallate | Not applicable | 0.3 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | 36.7 after 3 days | MENG 2002 | |||||
| 5-(3',4',-dihydroxyphenyl)-γ-valerolactone | Not applicable | 0.3 % of ad libitum drinking fluid | 0 | 5 | Trace amount | MENG 2002 | ||||||
| 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone | Not applicable | 0.3 % of ad libitum drinking fluid | 0 | 5 | Trace amount | MENG 2002 | ||||||
| 5-(3',5'-dihydroxyphenyl)-γ-valerolactone | Not applicable | 0.3 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | MENG 2002 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| mouse studies | ||||||||||||
| Epigallocatechin 3-O-gallate-7-O-glucoside-4''-O-glucuronide | Not applicable | 200 mg/kg bw | Single dose | 4 | Detected (unquantified) | SANG 2008_02 | ||||||