Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Naringenin Not applicable 1 fruits/day 28 days 4 Detected (unquantified) Detected (unquantified) AMEER 1996
500 mg Single dose 1 4.84 Detected (unquantified) AMEER 1996
500 mg Single dose 6 0.38 Graph ISHII 2000
rat studies
Hesperetin Not applicable 0.5 % of diet 7 days 6 47 nmol after 24 hours 0.23 µmol/L after 24 hours SILBERBERG 2006
Isosakuranetin Not applicable 0.5 % of diet 7 days 6 79 nmol after 24 hours 0.12 µmol/L after 24 hours SILBERBERG 2006
Naringenin Not applicable 0.5 % of diet 7 days 6 5900 nmol after 24 hours 17 µmol/L after 24 hours SILBERBERG 2006
746.7 mg/kg bw Single dose 6 9 0.83 2.98 1252.24 Graph FANG 2006
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Naringin Not applicable 500 mg Single dose 6 0.02 Graph ISHII 2000
rat studies
Naringin Not applicable 746.7 mg/kg bw Single dose 6 0.75 6.51 5.34 6026.32 Graph FANG 2006