Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
7-Hydroxyenterolactone Not applicable 25 mg/kg bw Single dose 11 0.36 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 11.2 nmol after 24 hours SMEDS 2004
7-Hydroxymatairesinol Not applicable 25 mg/kg bw Single dose 11 2.88 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 3.71 nmol after 24 hours SMEDS 2004
Cyclolariciresinol Not applicable 25 mg/kg bw Single dose 11 735 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 863 nmol after 24 hours SMEDS 2004
Enterodiol Not applicable 25 mg/kg bw Single dose 11 113 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 11.2 nmol after 24 hours SMEDS 2004
Enterolactone Not applicable 25 mg/kg bw Single dose 11 33.2 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 896 nmol after 24 hours SMEDS 2004
Lariciresinol Not applicable 25 mg/kg bw Single dose 11 696 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 891 nmol after 24 hours SMEDS 2004
Matairesinol Not applicable 25 mg/kg bw Single dose 11 0.26 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 0.21 nmol after 24 hours SMEDS 2004
Secoisolariciresinol Not applicable 25 mg/kg bw Single dose 11 13.9 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 7 18.5 nmol after 24 hours SMEDS 2004