Showing all polyphenol metabolites originating from consumption of dietary polyphenol Oleuropein Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| Homovanillyl alcohol | Not applicable | 0.33 mg/kg bw/day | 80 days | 3 | 61.9 ng/mL after 80 days | BAZOTI 2009 | ||||||
| Hydroxytyrosol | Not applicable | 0.15 g/kg bw/day | 80 days | 1 | 1036.7 ng/ml after 80 days | BAZOTI 2005 | ||||||
| 100 mg/kg bw | Single dose | 3 | 2500 ng/mL after 24 hours | DEL BOCCIO 2003 | ||||||||
| Oleuropein | Not applicable | 0.33 mg/kg bw/day | 80 days | 3 | Trace amount | BAZOTI 2009 | ||||||
| 100 mg/kg bw | Single dose | 3 | 95 ng/mL after 24 hours | 2 | 0.37 |
|
DEL BOCCIO 2003 | |||||
| Tyrosol | Not applicable | 0.15 g/kg bw/day | 80 days | 3 | 814.5 ng/ml after 80 days | BAZOTI 2005 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| Hydroxytyrosol | Not applicable | 100 mg/kg bw | Single dose | 3 | 40 ng/mL after 24 hours | DEL BOCCIO 2003 | ||||||
| Oleuropein | Not applicable | 100 mg/kg bw | Single dose | 3 | 10 ng/mL after 24 hours | DEL BOCCIO 2003 | ||||||