Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
Homovanillyl alcohol Not applicable 0.33 mg/kg bw/day 80 days 3 61.9 ng/mL after 80 days BAZOTI 2009
Hydroxytyrosol Not applicable 0.15 g/kg bw/day 80 days 1 1036.7 ng/ml after 80 days BAZOTI 2005
100 mg/kg bw Single dose 3 2500 ng/mL after 24 hours DEL BOCCIO 2003
Oleuropein Not applicable 0.33 mg/kg bw/day 80 days 3 Trace amount BAZOTI 2009
100 mg/kg bw Single dose 3 95 ng/mL after 24 hours 2 0.37 Graph DEL BOCCIO 2003
Tyrosol Not applicable 0.15 g/kg bw/day 80 days 3 814.5 ng/ml after 80 days BAZOTI 2005
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
Hydroxytyrosol Not applicable 100 mg/kg bw Single dose 3 40 ng/mL after 24 hours DEL BOCCIO 2003
Oleuropein Not applicable 100 mg/kg bw Single dose 3 10 ng/mL after 24 hours DEL BOCCIO 2003