Showing all polyphenol metabolites originating from consumption of dietary polyphenol Chlorogenic acid, total Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| 2,4-Dihydroxybenzoic acid | Not applicable | 2 g/day | 7 days | 20 | 13 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 2-Hydroxy-2-phenylacetic acid | Not applicable | 2 g/day | 7 days | 20 | 6 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 2-Hydroxyhippuric acid | Not applicable | 2 g/day | 7 days | 20 | 9.2 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 2-Hydroxyphenylacetic acid | Not applicable | 2 g/day | 7 days | 20 | 80 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 3,4-Dihydroxyphenylacetic acid | Not applicable | 2 g/day | 7 days | 20 | 24 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 3,5-Dihydroxybenzoic acid | Not applicable | 2 g/day | 7 days | 20 | 42 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 3-Hydroxybenzoic acid | Not applicable | 2 g/day | 7 days | 20 | 6.3 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 3-Hydroxyphenylacetic acid | Not applicable | 2 g/day | 7 days | 20 | 18 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 4-Hydroxybenzoic acid | Not applicable | 2 g/day | 7 days | 20 | 29 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 4-Hydroxyphenylacetic acid | Not applicable | 2 g/day | 7 days | 20 | 160 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| 5-Caffeoylquinic acid | Not applicable | 2 g/day | 7 days | 20 | 100 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Benzoic acid | Not applicable | 2 g/day | 7 days | 20 | 12 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Caffeic acid | Not applicable | 2 g/day | 7 days | 20 | 56 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Dihydrocaffeic acid | Not applicable | 2 g/day | 7 days | 20 | 97 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Ferulic acid | Not applicable | 2 g/day | 7 days | 20 | 71 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Hippuric acid | Not applicable | 2 g/day | 7 days | 20 | 8100 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Homovanillic acid | Not applicable | 2 g/day | 7 days | 20 | 41 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| m-Coumaric acid | Not applicable | 2 g/day | 7 days | 20 | 20 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| p-Coumaric acid | Not applicable | 2 g/day | 7 days | 20 | 4.2 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Phenylacetic acid | Not applicable | 2 g/day | 7 days | 20 | 20 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Protocatechuic acid | Not applicable | 2 g/day | 7 days | 20 | 27 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Syringic acid | Not applicable | 2 g/day | 7 days | 20 | 13.6 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| Vanillic acid | Not applicable | 2 g/day | 7 days | 20 | 102 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| rat studies | ||||||||||||
| 3,4-Dihydroxyphenylacetic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.28 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 3-Hydroxybenzoic acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
GONTHIER 2003_01 | ||||||
| 3-Hydroxyhippuric acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
GONTHIER 2003_01 | ||||||
| 3-Hydroxyphenylacetic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.36 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 3-Hydroxyphenylpropionic acid | Not applicable | 250 µmol/day | 8 days | 8 | 36.5 |
|
12.9 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| 4-Hydroxybenzoic acid | Not applicable | 250 µmol/day | 8 days | 8 | 4 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 4-Hydroxyhippuric acid | Not applicable | 250 µmol/day | 8 days | 8 | 2.16 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 5-Caffeoylquinic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.86 |
|
GONTHIER 2003_01 | |||||
| Caffeic acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
GONTHIER 2003_01 | ||||||
| Dihydrocaffeic acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
GONTHIER 2003_01 | ||||||
| Ferulic acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
0.4 µmol/L after 8 days | GONTHIER 2003_01 | |||||
| Hippuric acid | Not applicable | 250 µmol/day | 8 days | 8 | 36.5 |
|
98.2 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| Isoferulic acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
4.5 µmol/L after 8 days | GONTHIER 2003_01 | |||||
| m-Coumaric acid | Not applicable | 250 µmol/day | 8 days | 8 | 1.6 |
|
1.9 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| p-Coumaric acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.16 µmol after 8 days | GONTHIER 2003_01 | ||||||