Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
2,4-Dihydroxybenzoic acid Not applicable 2 g/day 7 days 20 13 µmol/24h after 1 weeks OLTHOF 2003
2-Hydroxy-2-phenylacetic acid Not applicable 2 g/day 7 days 20 6 µmol/24h after 1 weeks OLTHOF 2003
2-Hydroxyhippuric acid Not applicable 2 g/day 7 days 20 9.2 µmol/24h after 1 weeks OLTHOF 2003
2-Hydroxyphenylacetic acid Not applicable 2 g/day 7 days 20 80 µmol/24h after 1 weeks OLTHOF 2003
3,4-Dihydroxyphenylacetic acid Not applicable 2 g/day 7 days 20 24 µmol/24h after 1 weeks OLTHOF 2003
3,5-Dihydroxybenzoic acid Not applicable 2 g/day 7 days 20 42 µmol/24h after 1 weeks OLTHOF 2003
3-Hydroxybenzoic acid Not applicable 2 g/day 7 days 20 6.3 µmol/24h after 1 weeks OLTHOF 2003
3-Hydroxyphenylacetic acid Not applicable 2 g/day 7 days 20 18 µmol/24h after 1 weeks OLTHOF 2003
4-Hydroxybenzoic acid Not applicable 2 g/day 7 days 20 29 µmol/24h after 1 weeks OLTHOF 2003
4-Hydroxyphenylacetic acid Not applicable 2 g/day 7 days 20 160 µmol/24h after 1 weeks OLTHOF 2003
5-Caffeoylquinic acid Not applicable 2 g/day 7 days 20 100 µmol/24h after 1 weeks OLTHOF 2003
Benzoic acid Not applicable 2 g/day 7 days 20 12 µmol/24h after 1 weeks OLTHOF 2003
Caffeic acid Not applicable 2 g/day 7 days 20 56 µmol/24h after 1 weeks OLTHOF 2003
Dihydrocaffeic acid Not applicable 2 g/day 7 days 20 97 µmol/24h after 1 weeks OLTHOF 2003
Ferulic acid Not applicable 2 g/day 7 days 20 71 µmol/24h after 1 weeks OLTHOF 2003
Hippuric acid Not applicable 2 g/day 7 days 20 8100 µmol/24h after 1 weeks OLTHOF 2003
Homovanillic acid Not applicable 2 g/day 7 days 20 41 µmol/24h after 1 weeks OLTHOF 2003
m-Coumaric acid Not applicable 2 g/day 7 days 20 20 µmol/24h after 1 weeks OLTHOF 2003
p-Coumaric acid Not applicable 2 g/day 7 days 20 4.2 µmol/24h after 1 weeks OLTHOF 2003
Phenylacetic acid Not applicable 2 g/day 7 days 20 20 µmol/24h after 1 weeks OLTHOF 2003
Protocatechuic acid Not applicable 2 g/day 7 days 20 27 µmol/24h after 1 weeks OLTHOF 2003
Syringic acid Not applicable 2 g/day 7 days 20 13.6 µmol/24h after 1 weeks OLTHOF 2003
Vanillic acid Not applicable 2 g/day 7 days 20 102 µmol/24h after 1 weeks OLTHOF 2003
rat studies
3,4-Dihydroxyphenylacetic acid Not applicable 250 µmol/day 8 days 8 0.28 µmol after 8 days GONTHIER 2003_01
3-Hydroxybenzoic acid Not applicable 250 µmol/day 8 days 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GONTHIER 2003_01
3-Hydroxyhippuric acid Not applicable 250 µmol/day 8 days 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GONTHIER 2003_01
3-Hydroxyphenylacetic acid Not applicable 250 µmol/day 8 days 8 0.36 µmol after 8 days GONTHIER 2003_01
3-Hydroxyphenylpropionic acid Not applicable 250 µmol/day 8 days 8 36.5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 12.9 µmol/L after 8 days GONTHIER 2003_01
4-Hydroxybenzoic acid Not applicable 250 µmol/day 8 days 8 4 µmol after 8 days GONTHIER 2003_01
4-Hydroxyhippuric acid Not applicable 250 µmol/day 8 days 8 2.16 µmol after 8 days GONTHIER 2003_01
5-Caffeoylquinic acid Not applicable 250 µmol/day 8 days 8 0.86 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GONTHIER 2003_01
Caffeic acid Not applicable 250 µmol/day 8 days 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GONTHIER 2003_01
Dihydrocaffeic acid Not applicable 250 µmol/day 8 days 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GONTHIER 2003_01
Ferulic acid Not applicable 250 µmol/day 8 days 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 0.4 µmol/L after 8 days GONTHIER 2003_01
Hippuric acid Not applicable 250 µmol/day 8 days 8 36.5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 98.2 µmol/L after 8 days GONTHIER 2003_01
Isoferulic acid Not applicable 250 µmol/day 8 days 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 4.5 µmol/L after 8 days GONTHIER 2003_01
m-Coumaric acid Not applicable 250 µmol/day 8 days 8 1.6 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 1.9 µmol/L after 8 days GONTHIER 2003_01
p-Coumaric acid Not applicable 250 µmol/day 8 days 8 0.16 µmol after 8 days GONTHIER 2003_01