Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Hesperetin Food administered
Generic food
150 mL Single dose 7 5.3 0.14 1.1 195.5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GARDANA 2007_02
5 mL/kg bw Single dose 16 4.06 7 0.48 1.16 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 NIELSEN 2006
300 g Single dose 129 3.9 BRETT 2009
300 g Single dose 20 4.63 6.2 0.1 346 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BRETT 2009
Naringenin Food administered
Generic food
150 mL Single dose 7 5 0.06 1.3 53.9 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GARDANA 2007_02
300 g Single dose 129 14.5 BRETT 2009
300 g Single dose 20 10.2 4.46 0.05 176 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BRETT 2009
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Cyanidin 3-O-(6''-malonyl-glucoside) Food administered
Generic food
1 L Single dose 6 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 VITAGLIONE 2007
Cyanidin 3-O-glucoside Food administered
Generic food
1 L Single dose 6 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 0.5 0 7 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 VITAGLIONE 2007
Protocatechuic acid Food administered
Generic food
1 L Single dose 6 2 0.49 11 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 VITAGLIONE 2007
Hesperetin 3'-O-glucuronide Generic food 300 g Single dose 20 Detected (unquantified) Detected (unquantified) BRETT 2009
Hesperetin 7-O-glucuronide Generic food 300 g Single dose 129 Detected (unquantified) BRETT 2009
300 g Single dose 20 Detected (unquantified) Detected (unquantified) BRETT 2009
Naringenin 4'-O-glucuronide Generic food 300 g Single dose 129 Detected (unquantified) BRETT 2009
300 g Single dose 20 Detected (unquantified) Detected (unquantified) BRETT 2009
Naringenin 7-O-glucuronide Generic food 300 g Single dose 129 Detected (unquantified) BRETT 2009
300 g Single dose 20 Detected (unquantified) Detected (unquantified) BRETT 2009