Showing all polyphenol metabolites originating from consumption of Cranberry powder diet, high fructose Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| 3,4-Dihydroxyphenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.32 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 3-Hydroxybenzoic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.6 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 3-Hydroxyphenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 8 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 3-Hydroxyphenylpropionic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 6.37 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 4-Hydroxybenzoic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 7.2 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 4-Hydroxyphenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 31.8 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 5-Caffeoylquinic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | Detected (unquantified) | PRIOR 2010 | ||||||
| Caffeic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.89 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Ferulic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 2.4 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Gentisic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.15 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Hippuric acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 218 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| m-Coumaric acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.89 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| p-Coumaric acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 8.76 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Phenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.14 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Protocatechuic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.03 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Vanillic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.84 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| 3,4-Dihydroxyphenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.72 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 3-Hydroxybenzoic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.22 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 3-Hydroxyphenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 3.03 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 3-Hydroxyphenylpropionic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.81 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 4-Hydroxybenzoic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.98 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 4-Hydroxyphenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 7.18 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| 5-Caffeoylquinic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | Detected (unquantified) | PRIOR 2010 | ||||||
| Caffeic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.04 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Ferulic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.11 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Gallic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | Detected (unquantified) | PRIOR 2010 | ||||||
| Gentisic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.09 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Hippuric acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 115 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| m-Coumaric acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.14 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| p-Coumaric acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 1.26 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Phenylacetic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.13 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Protocatechuic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.26 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| Vanillic acid |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.11 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||