Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
3,4-Dihydroxyphenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 1.32 µg/mg creatinine after 30 days PRIOR 2010
3-Hydroxybenzoic acid Food administered
6.6 mg/kg bw Single dose 10 1.6 µg/mg creatinine after 30 days PRIOR 2010
3-Hydroxyphenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 8 µg/mg creatinine after 30 days PRIOR 2010
3-Hydroxyphenylpropionic acid Food administered
6.6 mg/kg bw Single dose 10 6.37 µg/mg creatinine after 30 days PRIOR 2010
4-Hydroxybenzoic acid Food administered
6.6 mg/kg bw Single dose 10 7.2 µg/mg creatinine after 30 days PRIOR 2010
4-Hydroxyphenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 31.8 µg/mg creatinine after 30 days PRIOR 2010
5-Caffeoylquinic acid Food administered
6.6 mg/kg bw Single dose 10 Detected (unquantified) PRIOR 2010
Caffeic acid Food administered
6.6 mg/kg bw Single dose 10 0.89 µg/mg creatinine after 30 days PRIOR 2010
Ferulic acid Food administered
6.6 mg/kg bw Single dose 10 2.4 µg/mg creatinine after 30 days PRIOR 2010
Gentisic acid Food administered
6.6 mg/kg bw Single dose 10 0.15 µg/mg creatinine after 30 days PRIOR 2010
Hippuric acid Food administered
6.6 mg/kg bw Single dose 10 218 µg/mg creatinine after 30 days PRIOR 2010
m-Coumaric acid Food administered
6.6 mg/kg bw Single dose 10 0.89 µg/mg creatinine after 30 days PRIOR 2010
p-Coumaric acid Food administered
6.6 mg/kg bw Single dose 10 8.76 µg/mg creatinine after 30 days PRIOR 2010
Phenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 0.14 µg/mg creatinine after 30 days PRIOR 2010
Protocatechuic acid Food administered
6.6 mg/kg bw Single dose 10 1.03 µg/mg creatinine after 30 days PRIOR 2010
Vanillic acid Food administered
6.6 mg/kg bw Single dose 10 1.84 µg/mg creatinine after 30 days PRIOR 2010
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
3,4-Dihydroxyphenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 0.72 µg/mg creatinine after 30 days PRIOR 2010
3-Hydroxybenzoic acid Food administered
6.6 mg/kg bw Single dose 10 0.22 µg/mg creatinine after 30 days PRIOR 2010
3-Hydroxyphenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 3.03 µg/mg creatinine after 30 days PRIOR 2010
3-Hydroxyphenylpropionic acid Food administered
6.6 mg/kg bw Single dose 10 1.81 µg/mg creatinine after 30 days PRIOR 2010
4-Hydroxybenzoic acid Food administered
6.6 mg/kg bw Single dose 10 1.98 µg/mg creatinine after 30 days PRIOR 2010
4-Hydroxyphenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 7.18 µg/mg creatinine after 30 days PRIOR 2010
5-Caffeoylquinic acid Food administered
6.6 mg/kg bw Single dose 10 Detected (unquantified) PRIOR 2010
Caffeic acid Food administered
6.6 mg/kg bw Single dose 10 0.04 µg/mg creatinine after 30 days PRIOR 2010
Ferulic acid Food administered
6.6 mg/kg bw Single dose 10 0.11 µg/mg creatinine after 30 days PRIOR 2010
Gallic acid Food administered
6.6 mg/kg bw Single dose 10 Detected (unquantified) PRIOR 2010
Gentisic acid Food administered
6.6 mg/kg bw Single dose 10 0.09 µg/mg creatinine after 30 days PRIOR 2010
Hippuric acid Food administered
6.6 mg/kg bw Single dose 10 115 µg/mg creatinine after 30 days PRIOR 2010
m-Coumaric acid Food administered
6.6 mg/kg bw Single dose 10 0.14 µg/mg creatinine after 30 days PRIOR 2010
p-Coumaric acid Food administered
6.6 mg/kg bw Single dose 10 1.26 µg/mg creatinine after 30 days PRIOR 2010
Phenylacetic acid Food administered
6.6 mg/kg bw Single dose 10 0.13 µg/mg creatinine after 30 days PRIOR 2010
Protocatechuic acid Food administered
6.6 mg/kg bw Single dose 10 0.26 µg/mg creatinine after 30 days PRIOR 2010
Vanillic acid Food administered
6.6 mg/kg bw Single dose 10 0.11 µg/mg creatinine after 30 days PRIOR 2010