Showing all polyphenol metabolites originating from consumption of Soy protein isolate Metabolism

  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered		 Dose
duration		 Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Coumestrol Not applicable 2 mg/day 9 days 12 38.6 nmol after 24 hours XU 2000
2 mg/day 93 days 18 35.4 nmol after 24 hours XU 2000
Daidzein Not applicable 2 mg/day 9 days 12 9528 nmol after 24 hours XU 2000
2 mg/day 93 days 18 14059 nmol after 24 hours XU 2000
50 g Single dose 1 13 960 ng/mL after 24 hours MOORS 2007
Dihydrodaidzein Not applicable 2 mg/day 9 days 12 2799 nmol after 24 hours XU 2000
2 mg/day 93 days 18 7383 nmol after 24 hours XU 2000
Enterodiol Not applicable 2 mg/day 9 days 12 296 nmol after 24 hours XU 2000
2 mg/day 93 days 18 553 nmol after 24 hours XU 2000
Enterolactone Not applicable 2 mg/day 93 days 18 3820 nmol after 24 hours XU 2000
Episesaminol Not applicable 2 mg/day 9 days 12 2782 nmol after 24 hours XU 2000
Equol Not applicable 2 mg/day 9 days 12 438 nmol after 24 hours XU 2000
2 mg/day 93 days 18 1097 nmol after 24 hours XU 2000
50 g Single dose 1 24 1740 ng/mL after 24 hours MOORS 2007
Genistein Not applicable 2 mg/day 9 days 12 14200 nmol after 24 hours XU 2000
2 mg/day 93 days 18 13148 nmol after 24 hours XU 2000
50 g Single dose 1 6 820 ng/mL after 24 hours MOORS 2007
Glycitein Not applicable 2 mg/day 9 days 12 2510 nmol after 24 hours XU 2000
2 mg/day 93 days 18 3674 nmol after 24 hours XU 2000
Matairesinol Not applicable 2 mg/day 9 days 12 13.9 nmol after 24 hours XU 2000
2 mg/day 93 days 18 25.6 nmol after 24 hours XU 2000
O-Desmethylangolensin Not applicable 2 mg/day 9 days 12 20292 nmol after 24 hours XU 2000
2 mg/day 93 days 18 10405 nmol after 24 hours XU 2000
rat studies
Daidzein Food administered
 0 1 days 26 30 nmol after 24 hours CIMINO 1999
0 0 9 79.52 nmol/mL after 24 hours CHANG 2009
Dihydrodaidzein Food administered
 0 1 days 26 1.5 nmol after 24 hours CIMINO 1999
Dihydrogenistein Food administered
 0 1 days 26 0.5 nmol after 24 hours CIMINO 1999
Equol Food administered
 0 1 days 26 6.5 nmol after 24 hours CIMINO 1999
0 0 9 364.94 nmol/mL after 24 hours CHANG 2009
Genistein Food administered
 0 1 days 26 24 nmol after 24 hours CIMINO 1999
0 0 9 29.2 nmol/mL after 24 hours CHANG 2009
Glycitein Food administered
 0 1 days 26 5 nmol after 24 hours CIMINO 1999
0 0 9 33.34 nmol/mL after 24 hours CHANG 2009
O-Desmethylangolensin Food administered
 0 1 days 26 1 nmol after 24 hours CIMINO 1999
pig studies
Daidzein Food administered
 24 % of diet 4 days 2 17.93 nmol/mL after 4 days CHANG 2009
Genistein Food administered
 24 % of diet 4 days 2 17.18 nmol/mL after 4 days CHANG 2009
Glycitein Food administered
 24 % of diet 4 days 2 8.13 nmol/mL after 4 days CHANG 2009
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered		 Dose
duration		 Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
Daidzein Food administered
 0 1 days 26 10 nmol after 24 hours CIMINO 1999
0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 45.36 nmol/mL after 24 hours CHANG 2009
Dihydrodaidzein Food administered
 0 1 days 26 1 nmol after 24 hours CIMINO 1999
0 Single dose 5 Detected (unquantified) FANG 2002
Dihydrogenistein Food administered
 0 1 days 26 0.5 nmol after 24 hours CIMINO 1999
Equol Food administered
 0 1 days 26 3.5 nmol after 24 hours CIMINO 1999
0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 172.83 nmol/mL after 24 hours CHANG 2009
Genistein Food administered
 0 1 days 26 11 nmol after 24 hours CIMINO 1999
0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 8.91 nmol/mL after 24 hours CHANG 2009
Glycitein Food administered
 0 1 days 26 2.5 nmol after 24 hours CIMINO 1999
0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 24.15 nmol/mL after 24 hours CHANG 2009
O-Desmethylangolensin Food administered
 0 1 days 26 0.5 nmol after 24 hours CIMINO 1999
0 Single dose 5 Detected (unquantified) FANG 2002
6''-O-Malonyldaidzin Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
Daidzein 4'-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 Detected (unquantified) CHANG 2009
Daidzein 7-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 Detected (unquantified) CHANG 2009
Daidzin Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
Daidzin 4'-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
Dihydrodaidzein 7-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
Equol 4'-O-glucuronide Food administered
 0 0 9 Detected (unquantified) CHANG 2009
Equol 7-O-glucuronide Food administered
 0 0 9 Detected (unquantified) CHANG 2009
Genistein 4',7-O-diglucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
Genistein 4'-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 Detected (unquantified) CHANG 2009
Genistein 5-O-glucuronide Food administered
 0 0 9 Detected (unquantified) CHANG 2009
Genistein 7-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
0 0 9 Detected (unquantified) CHANG 2009
Glycitein 4'-O-glucuronide Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
Glycitein 7-O-glucuronide Food administered
 0 0 9 Detected (unquantified) CHANG 2009
Glycitin Food administered
 0 Single dose 5 Detected (unquantified) FANG 2002
pig studies
Daidzein Food administered
 24 % of diet 4 days 2 3.49 nmol/mL after 4 days CHANG 2009
Daidzein 4'-O-glucuronide Food administered
 24 % of diet 4 days 2 Detected (unquantified) CHANG 2009
Daidzein 7-O-glucuronide Food administered
 24 % of diet 4 days 2 Detected (unquantified) CHANG 2009
Genistein Food administered
 24 % of diet 4 days 2 3.14 nmol/mL after 4 days CHANG 2009
Genistein 4'-O-glucuronide Food administered
 24 % of diet 4 days 2 Detected (unquantified) CHANG 2009
Genistein 5-O-glucuronide Food administered
 24 % of diet 4 days 2 Detected (unquantified) CHANG 2009
Genistein 7-O-glucuronide Food administered
 24 % of diet 4 days 2 Detected (unquantified) CHANG 2009
Glycitein Food administered
 24 % of diet 4 days 2 1.26 nmol/mL after 4 days CHANG 2009
Glycitein 7-O-glucuronide Food administered
 24 % of diet 4 days 2 Detected (unquantified) CHANG 2009