Showing experiments where Secoisolariciresinol has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| high-isoflavone burger |
Food administered |
1 burger/day | 17 days | 22 | 105 nmol/day after 17 days | ROWLAND 2000 | ||||||
| low-isoflavone burger |
Food administered |
1 burger/day | 17 days | 21 | 86 nmol/day after 17 days | ROWLAND 2000 | ||||||
| processed flaxseed incorporated into bread |
Food administered Generic food |
25 g | 7 days | 9 | 2.52 µmol/24h after 7 days | NESBITT 1999 | ||||||
| processed flaxseed incorporated into muffin |
Food administered Generic food |
25 g | 7 days | 9 | 2.5 µmol/24h after 7 days | NESBITT 1999 | ||||||
| raw ground flaxseed |
Food administered Generic food |
5 g | Single dose | 9 | 0.22 µmol/24h after 7 days | NESBITT 1999 | ||||||
| raw ground flaxseed |
Food administered Generic food |
15 g | 7 days | 9 | 0.87 µmol/24h after 7 days | NESBITT 1999 | ||||||
| raw ground flaxseed |
Food administered Generic food |
25 g | 8 days | 9 | 1.95 µmol/24h after 7 days | NESBITT 1999 | ||||||
| rat studies | ||||||||||||
| 3H-secoisolariciresinol diglycoside | Not applicable | 3.7 kBq/g bw | Single dose | 12 | 14 | RICKARD 2000 | ||||||
| 7-hydroxymatairesinol | Not applicable | 25 mg/kg bw | Single dose | 11 | 51.3 nmol after 24 hours | SMEDS 2004 | ||||||
| 7-hydroxymatairesinol | Not applicable | 25 mg/kg bw | 10 days | 11 | 111 nmol after 24 hours | SMEDS 2004 | ||||||
| enterolactone | Not applicable | 25 mg/kg bw | Single dose | 6 | 1.65 µg after 24 hours | SAARINEN 2002 | ||||||
| lariciresinol | Not applicable | 25 mg/kg bw | 10 days | 7 | 18.5 nmol after 24 hours | SMEDS 2004 | ||||||
| lariciresinol | Not applicable | 25 mg/kg bw | Single dose | 11 | 13.9 nmol after 24 hours | SMEDS 2004 | ||||||
| secoisolariciresinol | Not applicable | 25 mg/kg bw | Single dose | 6 | 6.31 µg after 24 hours | SAARINEN 2002 | ||||||
| secoisolariciresinol diglycoside | Not applicable | 1.5 mg/day | 10 days | 12 | 16 | RICKARD 2000 | ||||||