Showing all polyphenol metabolites originating from consumption of dietary polyphenol (-)-Epicatechin Metabolism

  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered		 Dose
duration		 Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
(-)-Epicatechin Not applicable 200 mg Single dose 12 Graph Graph LOKE 2009
1,3,5-Trimethoxybenzene Not applicable 200 mg Single dose 12 Graph Graph LOKE 2009
3-O-Methylgallic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
3-Phenylpropionic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
4-Ethylbenzoic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
4-Ethylphenol Not applicable 200 mg Single dose 12 Graph LOKE 2009
4-O-Methylgallic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
5-(3',4',-dihydroxyphenyl)-γ-valerolactone Not applicable 200 mg Single dose 4 Graph MENG 2002
Benzoic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Dihydro-p-coumaric acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Dihydrocaffeic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Ferulic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Gallic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Methoxyphenylacetic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Protocatechuic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
Vanillic acid Not applicable 200 mg Single dose 12 Graph LOKE 2009
rat studies
(-)-Epicatechin Not applicable 10 mg/kg bw Single dose 5 Graph BABA 2001_01
172 µmol/kg bw Single dose 5 16.6 µmol after 24 hours 78.3 Graph BABA 2001_02
100 mg/kg bw Single dose 9 50 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 51 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 54 µmol/L after 5 days ABD EL MOHSEN 2002
3'-O-Methylepicatechin Not applicable 10 mg/kg bw Single dose 5 Graph BABA 2001_01
172 µmol/kg bw Single dose 5 9.45 µmol after 24 hours 78.3 Graph BABA 2001_02
100 mg/kg bw Single dose 9 16 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 20 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 22 µmol/L after 5 days ABD EL MOHSEN 2002
4'-O-Methylepicatechin Not applicable 100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered		 Dose
duration		 Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
(-)-Epicatechin Not applicable 1 g Single dose 4 443.6 ng/mL after 1 hours NATSUME 2003
3'-O-Methylepicatechin Not applicable 1 g Single dose 4 161.2 ng/mL after 1 hours NATSUME 2003
4'-O-Methyl-(-)-epicatechin 3'-O-glucuronide Not applicable 1 g Single dose 4 11.2 mg after 8 hours 292.9 ng/mL after 1 hours NATSUME 2003
Epicatechin 3'-O-glucuronide Not applicable 1 g Single dose 4 Detected (unquantified) 5246.2 ng/mL after 1 hours NATSUME 2003
rat studies
(-)-Epicatechin Not applicable 10 mg/kg bw Single dose 5 1231 nmol after 18 hours Graph BABA 2001_01
172 µmol/kg bw Single dose 5 5.23 µmol after 24 hours 0.87 Graph BABA 2001_02
100 mg/kg bw Single dose 9 4.3 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 3.7 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 5 µmol/L after 5 days ABD EL MOHSEN 2002
3'-O-Methyl-(-)-epicatechin 7-O-glucuronide Not applicable 20 mg/kg bw Single dose 13 Detected (unquantified) Detected (unquantified) NATSUME 2003
3'-O-Methylepicatechin Not applicable 20 mg/kg bw Single dose 13 Detected (unquantified) Detected (unquantified) NATSUME 2003
10 mg/kg bw Single dose 5 743 nmol after 18 hours Graph BABA 2001_01
172 µmol/kg bw Single dose 5 2.46 µmol after 24 hours 0.87 Graph BABA 2001_02
100 mg/kg bw Single dose 9 1.2 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 1 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 1.5 µmol/L after 5 days ABD EL MOHSEN 2002
Epicatechin 7-O-glucuronide Not applicable 20 mg/kg bw Single dose 13 Detected (unquantified) Detected (unquantified) NATSUME 2003
4'-O-Methylepicatechin Not applicable 100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002