Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
(-)-Epicatechin Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
1,3,5-Trimethoxybenzene Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
3-O-Methylgallic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
3-Phenylpropionic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
4-Ethylbenzoic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
4-Ethylphenol Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
4-O-Methylgallic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
5-(3',4',-dihydroxyphenyl)-γ-valerolactone Not applicable 200 mg Single dose 4 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 MENG 2002
Benzoic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Dihydro-p-coumaric acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Dihydrocaffeic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Ferulic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Gallic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Methoxyphenylacetic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Protocatechuic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
Vanillic acid Not applicable 200 mg Single dose 12 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 LOKE 2009
rat studies
(-)-Epicatechin Not applicable 10 mg/kg bw Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_01
172 µmol/kg bw Single dose 5 16.6 µmol after 24 hours 78.3 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
100 mg/kg bw Single dose 9 50 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 51 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 54 µmol/L after 5 days ABD EL MOHSEN 2002
3'-O-Methylepicatechin Not applicable 10 mg/kg bw Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_01
172 µmol/kg bw Single dose 5 9.45 µmol after 24 hours 78.3 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
100 mg/kg bw Single dose 9 16 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 20 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 22 µmol/L after 5 days ABD EL MOHSEN 2002
4'-O-Methylepicatechin Not applicable 100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
(-)-Epicatechin Not applicable 1 g Single dose 4 443.6 ng/mL after 1 hours NATSUME 2003
3'-O-Methylepicatechin Not applicable 1 g Single dose 4 161.2 ng/mL after 1 hours NATSUME 2003
4'-O-Methyl-(-)-epicatechin 3'-O-glucuronide Not applicable 1 g Single dose 4 11.2 mg after 8 hours 292.9 ng/mL after 1 hours NATSUME 2003
Epicatechin 3'-O-glucuronide Not applicable 1 g Single dose 4 Detected (unquantified) 5246.2 ng/mL after 1 hours NATSUME 2003
rat studies
(-)-Epicatechin Not applicable 10 mg/kg bw Single dose 5 1231 nmol after 18 hours Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_01
172 µmol/kg bw Single dose 5 5.23 µmol after 24 hours 0.87 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
100 mg/kg bw Single dose 9 4.3 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 3.7 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 5 µmol/L after 5 days ABD EL MOHSEN 2002
3'-O-Methyl-(-)-epicatechin 7-O-glucuronide Not applicable 20 mg/kg bw Single dose 13 Detected (unquantified) Detected (unquantified) NATSUME 2003
3'-O-Methylepicatechin Not applicable 20 mg/kg bw Single dose 13 Detected (unquantified) Detected (unquantified) NATSUME 2003
10 mg/kg bw Single dose 5 743 nmol after 18 hours Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_01
172 µmol/kg bw Single dose 5 2.46 µmol after 24 hours 0.87 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
100 mg/kg bw Single dose 9 1.2 µmol/L after 1 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 1 µmol/L after 10 days ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 1.5 µmol/L after 5 days ABD EL MOHSEN 2002
Epicatechin 7-O-glucuronide Not applicable 20 mg/kg bw Single dose 13 Detected (unquantified) Detected (unquantified) NATSUME 2003
4'-O-Methylepicatechin Not applicable 100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002
100 mg/kg bw Single dose 9 Detected (unquantified) ABD EL MOHSEN 2002