Showing all polyphenol metabolites originating from consumption of dietary polyphenol Caffeic acid Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| 3,4-Dihydroxyphenylacetic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.28 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 3-Hydroxybenzoic acid | Not applicable | 250 µmol/day | 8 days | 8 | 1.44 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 3-Hydroxyhippuric acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.8 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 3-Hydroxyphenylacetic acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.43 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 3-Hydroxyphenylpropionic acid | Not applicable | 250 µmol/day | 8 days | 8 | 63.2 µmol after 8 days | 1.4 µmol/L after 8 days | GONTHIER 2003_01 | |||||
| 4-Hydroxybenzoic acid | Not applicable | 250 µmol/day | 8 days | 8 | 3.2 µmol after 8 days | GONTHIER 2003_01 | ||||||
| 4-Hydroxyhippuric acid | Not applicable | 250 µmol/day | 8 days | 8 | 1.76 µmol after 8 days | GONTHIER 2003_01 | ||||||
| Caffeic acid | Not applicable | 250 µmol/day | 8 days | 8 | 181 µmol after 8 days | 41.3 µmol/L after 8 days | GONTHIER 2003_01 | |||||
| Dihydrocaffeic acid | Not applicable | 250 µmol/day | 8 days | 8 | 1.28 µmol after 8 days | GONTHIER 2003_01 | ||||||
| Ferulic acid | Not applicable | 250 µmol/day | 8 days | 8 | 14.5 µmol after 8 days | 7.3 µmol/L after 8 days | GONTHIER 2003_01 | |||||
| Hippuric acid | Not applicable | 250 µmol/day | 8 days | 8 | 22.9 | 428 µmol after 8 days | 54.2 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| m-Coumaric acid | Not applicable | 250 µmol/day | 8 days | 8 | 1.1 | 17.6 µmol after 8 days | GONTHIER 2003_01 | |||||
| p-Coumaric acid | Not applicable | 250 µmol/day | 8 days | 8 | 0.08 µmol after 8 days | GONTHIER 2003_01 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| 3,4-Dihydroxyphenyllactic acid methyl ester | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | ZHANG 2008_02 | ||||||
| 3-(3,4-Dihydroxyphenyl)-2-methoxypropionic acid | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | ZHANG 2008_02 | ||||||
| Caffeic acid | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| Caffeic acid 3-O-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| Caffeic acid 4-O-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| Caffeoyl C1-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| Ferulic acid | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | ZHANG 2008_02 | ||||||
| Ferulic acid 4-O-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | ZHANG 2008_02 | ||||||
| Feruloyl C1-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| Isoferulic acid 3-O-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| Isoferuloyl C1-glucuronide | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||