Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
7-Hydroxyenterolactone Not applicable 25 mg/kg bw Single dose 7 63.4 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 7 72.6 nmol after 24 hours SMEDS 2004
7-Hydroxymatairesinol Not applicable 25 mg/kg bw Single dose 7 553 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 7 725 nmol after 24 hours SMEDS 2004
Cyclolariciresinol Not applicable 25 mg/kg bw Single dose 7 1.89 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 7 2.8 nmol after 24 hours SMEDS 2004
Enterodiol Not applicable 25 mg/kg bw Single dose 7 0.57 nmol after 24 hours SMEDS 2004
25 mg/kg bw Single dose 6 1.03 µg after 24 hours SAARINEN 2002
25 mg/kg bw 10 days 7 13.4 nmol after 24 hours SMEDS 2004
Enterolactone Not applicable 25 mg/kg bw Single dose 7 50 nmol after 24 hours SMEDS 2004
25 mg/kg bw Single dose 6 76 54.7 µg after 24 hours SAARINEN 2002
25 mg/kg bw 10 days 7 950 nmol after 24 hours SMEDS 2004
Lariciresinol Not applicable 25 mg/kg bw Single dose 7 1.08 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 7 2.22 nmol after 24 hours SMEDS 2004
Matairesinol Not applicable 25 mg/kg bw Single dose 7 1.57 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 7 0.81 nmol after 24 hours SMEDS 2004