Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
7-Hydroxyenterolactone Not applicable 25 mg/kg bw Single dose 11 0.32 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 10.2 nmol after 24 hours SMEDS 2004
7-Hydroxymatairesinol Not applicable 25 mg/kg bw Single dose 11 0.07 nmol after 24 hours SMEDS 2004
Cyclolariciresinol Not applicable 25 mg/kg bw Single dose 11 2.22 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 2.14 nmol after 24 hours SMEDS 2004
Enterodiol Not applicable 25 mg/kg bw Single dose 11 75.5 nmol after 24 hours SMEDS 2004
25 mg/kg bw Single dose 6 0.46 µg after 24 hours SAARINEN 2002
25 mg/kg bw 10 days 11 675 nmol after 24 hours SMEDS 2004
Enterolactone Not applicable 25 mg/kg bw Single dose 11 27.7 nmol after 24 hours SMEDS 2004
25 mg/kg bw Single dose 6 59 18.2 µg after 24 hours SAARINEN 2002
25 mg/kg bw 10 days 11 1570 nmol after 24 hours SMEDS 2004
Lariciresinol Not applicable 25 mg/kg bw Single dose 11 1.47 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 2.22 nmol after 24 hours SMEDS 2004
Matairesinol Not applicable 25 mg/kg bw Single dose 11 0.07 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 0.2 nmol after 24 hours SMEDS 2004
Secoisolariciresinol Not applicable 25 mg/kg bw Single dose 11 51.3 nmol after 24 hours SMEDS 2004
25 mg/kg bw 10 days 11 111 nmol after 24 hours SMEDS 2004