Showing all polyphenol metabolites originating from consumption of Tea [green], powder Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| (-)-Epicatechin |
Food administered |
1.2 g | Single dose | 5 |
|
LI 2000 | ||||||
| 2.4 g | Single dose | 1 | 17.03 µmol after 6 days | LI 2000 | ||||||||
| (-)-Epigallocatechin |
Food administered |
1.2 g | Single dose | 5 |
|
LI 2000 | ||||||
| 2.4 g | Single dose | 1 | 56.54 µmol after 6 days | LI 2000 | ||||||||
| 20 mg/kg bw | Single dose | 4 | 14 | 1.02 |
|
MENG 2001 | ||||||
| 5-(3',4',-dihydroxyphenyl)-γ-valerolactone |
Food administered |
20 mg/kg bw | Single dose | 5 |
|
|
LI 2000 | |||||
| 1.2 g | Single dose | 5 |
|
LI 2000 | ||||||||
| 2.4 g | Single dose | 1 | 153.41 µmol after 6 days | LI 2000 | ||||||||
| 20 mg/kg bw | Single dose | 4 | Detected (unquantified) | Detected (unquantified) | MENG 2002 | |||||||
| 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone |
Food administered |
20 mg/kg bw | Single dose | 5 |
|
|
LI 2000 | |||||
| 1.2 g | Single dose | 5 |
|
LI 2000 | ||||||||
| 2.4 g | Single dose | 1 | 524.34 µmol after 6 days | LI 2000 | ||||||||
| 20 mg/kg bw | Single dose | 4 | Detected (unquantified) | Detected (unquantified) | MENG 2002 | |||||||
| (-)-Epigallocatechin 3-O-gallate |
Food administered |
20 mg/kg bw | Single dose | 4 | 26.7 |
|
2 | 0.14 | 2.7 | 668 |
|
MENG 2002 |
| 4''-O-Methylepigallocatechin 3-O-gallate |
Food administered |
20 mg/kg bw | Single dose | 4 | Trace amount | Trace amount | MENG 2002 | |||||
| 4',4"-O-Dimethylepigallocatechin 3-O-gallate |
Food administered |
20 mg/kg bw | Single dose | 4 |
|
2 | 0.02 | 4.1 | 77.5 |
|
MENG 2002 | |
| 4'-O-Methylepigallocatechin |
Food administered |
20 mg/kg bw | Single dose | 4 | 52 | 4.39 |
|
MENG 2001 | ||||
| 5-(3',5'-dihydroxyphenyl)-γ-valerolactone |
Food administered |
20 mg/kg bw | Single dose | 4 | Detected (unquantified) | 12 | 0.36 | MENG 2002 | ||||
| mouse studies | ||||||||||||
| (-)-Epigallocatechin 3-O-gallate |
Food administered |
0.6 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | 63.3 after 3 days | MENG 2002 | |||||
| 4',4"-O-Dimethylepigallocatechin 3-O-gallate |
Food administered |
0.6 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | 31 after 3 days | MENG 2002 | |||||
| 5-(3',4',-dihydroxyphenyl)-γ-valerolactone |
Food administered |
0.6 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | MENG 2002 | ||||||
| 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone |
Food administered |
0.6 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | MENG 2002 | ||||||
| 5-(3',5'-dihydroxyphenyl)-γ-valerolactone |
Food administered |
0.6 % of ad libitum drinking fluid | 0 | 5 | Detected (unquantified) | MENG 2002 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| (-)-Epicatechin | Not applicable | 1.2 g | Single dose | 5 | Detected (unquantified) | LI 2001 | ||||||
| (-)-Epigallocatechin | Not applicable | 1.2 g | Single dose | 5 | Detected (unquantified) | LI 2001 | ||||||
| (-)-Epigallocatechin 3-O-glucuronide | Not applicable | 1.2 g | Single dose | 5 | Detected (unquantified) | LI 2001 | ||||||
| Hippuric acid |
Food administered |
6 g | Single dose | 17 | 4.22 mmol after 4 days | MULDER 2005 | ||||||
| (-)-Epigallocatechin 3'-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| (-)-Epigallocatechin 7-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 4'-O-Methyl-(-)-epicatechin 3'-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 4'-O-Methyl-(-)-epigallocatechin 3'-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 4'-O-Methyl-(-)-epigallocatechin 7-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 5-(3',4',-dihydroxyphenyl)-γ-valerolactone | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 5-(3',5'-dihydroxyphenyl)-γ-valerolactone | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| 5-(3',5'-dihydroxyphenyl)-γ-valerolactone 3-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| Epicatechin 3'-O-glucuronide | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||
| Procyanidin dimer B4 | Not applicable | 3 g | Single dose | 3 | Detected (unquantified) | SANG 2008_01 | ||||||