Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
extra virgin olive oil Food administered
Generic food
30 mL Single dose 6 VISIOLI 2003
olive oil sample A Food administered
50 mL Single dose 6 367 µg after 24 hours VISIOLI 2000_02
olive oil sample B Food administered
50 mL Single dose 6 749 µg after 24 hours VISIOLI 2000_02
olive oil sample C Food administered
50 mL Single dose 6 1137 µg after 24 hours VISIOLI 2000_02
olive oil sample D Food administered
50 mL Single dose 6 1567 µg after 24 hours VISIOLI 2000_02
phenol-poor olive oil with 13.3 mg hydroxytyrosol Food administered
50 mL Single dose 6 749 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 19.2 mg hydroxytyrosol Food administered
50 mL Single dose 6 1137 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 23.2 mg hydroxytyrosol Food administered
50 mL Single dose 6 1567 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 7 mg hydroxytyrosol Food administered
50 mL Single dose 6 367 µg after 24 hours CARUSO 2001
refined olive oil containing phenolic extract Not applicable 30 mL Single dose 6 Trace amount VISIOLI 2003
synthetic hydroxytyrosol with 125 mL natural yoghurt Not applicable 20 mg Single dose 6 9 µmol/L after 24 hours VISIOLI 2003
virgin olive oil Food administered
Generic food
25 mL Single dose 6 122.9 µg after 12 hours 0.88 0.01 10.43 MIRO-CASAS 2003
rat studies
extra virgin olive oil Generic food 1.1 g/kg bw/day 80 days 3 53.5 ng/mL after 80 days BAZOTI 2009
extra virgin olive oil supplemented with 9.5 µg hydroxytyrosol Food administered
Generic food
500 µL Single dose 6 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 VISIOLI 2003
oleuropein Not applicable 0.33 mg/kg bw/day 80 days 3 61.9 ng/mL after 80 days BAZOTI 2009
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
virgin olive oil Food administered
Generic food
25 mL Single dose 6 7.5 µg after 12 hours MIRO-CASAS 2003