Showing experiments where Hydroxytyrosol has been detected in biofluids Metabolism

  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
extra virgin olive oil Food administered
Generic food 		30 mL Single dose 6 VISIOLI 2003
olive oil sample A Food administered
 50 mL Single dose 6 312 µg after 24 hours VISIOLI 2000_02
olive oil sample A Not applicable 50 mL Single dose 6 29 250 µg after 24 hours VISIOLI 2000_01
olive oil sample B Food administered
 50 mL Single dose 6 598 µg after 24 hours VISIOLI 2000_02
olive oil sample B Not applicable 50 mL Single dose 6 64 1375 µg after 24 hours VISIOLI 2000_01
olive oil sample C Food administered
 50 mL Single dose 6 873 µg after 24 hours VISIOLI 2000_02
olive oil sample C Not applicable 50 mL Single dose 6 35 1150 µg after 24 hours VISIOLI 2000_01
olive oil sample D Food administered
 50 mL Single dose 6 1024 µg after 24 hours VISIOLI 2000_02
olive oil sample D Not applicable 50 mL Single dose 6 40 1600 µg after 24 hours VISIOLI 2000_01
phenol-poor olive oil with 13.3 mg hydroxytyrosol Food administered
 50 mL Single dose 6 1328 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 19.2 mg hydroxytyrosol Food administered
 50 mL Single dose 6 1112 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 23.2 mg hydroxytyrosol Food administered
 50 mL Single dose 6 1653 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 7 mg hydroxytyrosol Food administered
 50 mL Single dose 6 267 µg after 24 hours CARUSO 2001
refined olive oil containing phenolic extract Not applicable 30 mL Single dose 6 Trace amount VISIOLI 2003
synthetic hydroxytyrosol with 125 mL natural yoghurt Not applicable 20 mg Single dose 6 4 µmol/L after 24 hours VISIOLI 2003
virgin olive oil Food administered
Generic food 		50 mL Single dose 11 MIRO-CASAS 2001
virgin olive oil Food administered
Generic food 		25 mL Single dose 6 479.6 µg after 12 hours 0.58 0.11 46.82 MIRO-CASAS 2003
rat studies
extra virgin olive oil Food administered
Generic food 		50 g/kg bw/day 80 days 1 404.3 ng/mL after 80 days BAZOTI 2005
extra virgin olive oil supplemented with 9.5 µg hydroxytyrosol Food administered
Generic food 		500 µL Single dose 6 Graph VISIOLI 2003
oleuropein Not applicable 0.15 g/kg bw/day 80 days 1 1036.7 ng/ml after 80 days BAZOTI 2005
oleuropein in soya oil and water Not applicable 100 mg/kg bw Single dose 3 2500 ng/mL after 24 hours DEL BOCCIO 2003
olive mill waste water extract Food administered
 10 mg/kg bw Single dose 3 15 ng after 24 hours VISIOLI 2001
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
olive oil sample A Not applicable 50 mL Single dose 6 25 µg after 24 hours VISIOLI 2000_01
olive oil sample B Not applicable 50 mL Single dose 6 42 µg after 24 hours VISIOLI 2000_01
olive oil sample C Not applicable 50 mL Single dose 6 47 µg after 24 hours VISIOLI 2000_01
olive oil sample D Not applicable 50 mL Single dose 6 15 µg after 24 hours VISIOLI 2000_01
virgin olive oil Food administered
Generic food 		50 mL Single dose 11 47.3 µg after 24 hours MIRO-CASAS 2001
virgin olive oil Food administered
Generic food 		30 mL Single dose 5 Graph SUAREZ 2009
rat studies
oleuropein in soya oil and water Not applicable 100 mg/kg bw Single dose 3 40 ng/mL after 24 hours DEL BOCCIO 2003