Showing all polyphenol metabolites originating from consumption of Soy, milk Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Daidzein |
Food administered Generic food |
100 mL | Single dose | 12 |
|
6 | 0.47 | 4.35 |
|
KANO 2006 | ||
| 750 mL/day | 5 days | 11 | 148.35 µmol/24h after 5 days | 196.1 nmol/L after 5 days | BOLCA 2010 | |||||||
| 3 supplements/day | 5 days | 10 | 214.22 µmol/24h after 5 days | 315.79 nmol/L after 5 days | BOLCA 2010 | |||||||
| Dihydrodaidzein |
Food administered Generic food |
750 mL/day | 5 days | 11 | 12.58 µmol/24h after 5 days | 90.08 nmol/L after 5 days | BOLCA 2010 | |||||
| 3 supplements/day | 5 days | 10 | 18.21 µmol/24h after 5 days | 146.34 nmol/L after 5 days | BOLCA 2010 | |||||||
| Equol |
Food administered Generic food |
100 mL | Single dose | 5 | Detected (unquantified) | KANO 2006 | ||||||
| 750 mL/day | 5 days | 4 | 154.96 µmol/24h after 5 days | 590.93 nmol/L after 5 days | BOLCA 2010 | |||||||
| 3 supplements/day | 5 days | 3 | 287.6 µmol/24h after 5 days | 900.52 nmol/L after 5 days | BOLCA 2010 | |||||||
| Genistein |
Food administered Generic food |
100 mL | Single dose | 12 |
|
5.9 | 0.41 | 4.51 |
|
KANO 2006 | ||
| 750 mL/day | 5 days | 11 | 2077.7 µmol/24h after 5 days | 797.04 nmol/L after 5 days | BOLCA 2010 | |||||||
| 3 supplements/day | 5 days | 10 | 267.5 µmol/24h after 5 days | 217.89 nmol/L after 5 days | BOLCA 2010 | |||||||
| Glycitein |
Food administered Generic food |
100 mL | Single dose | 12 |
|
5.7 | 0.09 | 0.68 |
|
KANO 2006 | ||
| O-Desmethylangolensin |
Food administered Generic food |
750 mL/day | 5 days | 11 | 220.33 µmol/24h after 5 days | 130.25 nmol/L after 5 days | BOLCA 2010 | |||||
| 3 supplements/day | 5 days | 10 | 215.09 µmol/24h after 5 days | 137.68 nmol/L after 5 days | BOLCA 2010 | |||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Daidzein |
Food administered Generic food |
750 mL/day | 5 days | 3 | 33 nmol/L after 5 days | BOLCA 2010 | ||||||
| 3 supplements/day | 5 days | 3 | 49 nmol/L after 5 days | BOLCA 2010 | ||||||||
| Daidzein 4'-O-glucuronide |
Food administered Generic food |
750 mL/day | 5 days | 9 | 16 nmol/L after 5 days | BOLCA 2010 | ||||||
| 3 supplements/day | 5 days | 7 | 39 nmol/L after 5 days | BOLCA 2010 | ||||||||
| Daidzein 7-O-glucuronide |
Food administered Generic food |
750 mL/day | 5 days | 11 | 151 nmol/L after 5 days | BOLCA 2010 | ||||||
| 3 supplements/day | 5 days | 9 | 294 nmol/L after 5 days | BOLCA 2010 | ||||||||
| Genistein |
Food administered Generic food |
750 mL/day | 5 days | 2 | 67 nmol/L after 5 days | BOLCA 2010 | ||||||
| 3 supplements/day | 5 days | 9 | Trace amount | BOLCA 2010 | ||||||||
| Genistein 4'-O-glucuronide |
Food administered Generic food |
750 mL/day | 5 days | 6 | 14 nmol/L after 5 days | BOLCA 2010 | ||||||
| 3 supplements/day | 5 days | 2 | 4 nmol/L after 5 days | BOLCA 2010 | ||||||||
| Genistein 7-O-glucuronide |
Food administered Generic food |
750 mL/day | 5 days | 11 | 122 nmol/L after 5 days | BOLCA 2010 | ||||||
| 3 supplements/day | 5 days | 6 | 11 nmol/L after 5 days | BOLCA 2010 | ||||||||