Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Quercetin Not applicable 25 mg Single dose 10 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 SOLEAS 2001
rat studies
(+)-Catechin Not applicable 172 µmol/kg bw Single dose 5 8.85 µmol after 24 hours 66.4 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
0.12 g/100 g bw Single dose 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 1.3 µmol/L after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 37 µmol after 5 days GONTHIER 2003_02
3'-O-Methylcatechin Not applicable 172 µmol/kg bw Single dose 5 3.6 µmol after 24 hours 23 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
0.12 g/100 g bw Single dose 8 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 GONTHIER 2003_03
0.1 % of diet 5 days 5 43 µmol after 5 days GONTHIER 2003_02
3,4-Dihydroxyphenylacetic acid Not applicable 0.12 g/100 g bw Single dose 8 100.8 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 0.25 µmol after 5 days GONTHIER 2003_02
3-Hydroxybenzoic acid Not applicable 0.12 g/100 g bw Single dose 8 864 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 1.25 µmol after 5 days GONTHIER 2003_02
3-Hydroxyhippuric acid Not applicable 0.12 g/100 g bw Single dose 8 1067.2 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 1.45 µmol after 5 days GONTHIER 2003_02
3-Hydroxyphenylacetic acid Not applicable 0.12 g/100 g bw Single dose 8 191.2 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 0.4 µmol after 5 days GONTHIER 2003_02
3-Hydroxyphenylpropionic acid Not applicable 0.12 g/100 g bw Single dose 8 6588 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 0.25 µmol after 5 days GONTHIER 2003_02
3-Hydroxyphenylvaleric acid Not applicable 0.12 g/100 g bw Single dose 8 Detected (unquantified) GONTHIER 2003_03
0.1 % of diet 5 days 5 0.23 µmol after 5 days GONTHIER 2003_02
4-Hydroxybenzoic acid Not applicable 0.12 g/100 g bw Single dose 8 711.2 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 2.1 µmol after 5 days GONTHIER 2003_02
4-Hydroxyhippuric acid Not applicable 0.12 g/100 g bw Single dose 8 716 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 1.9 µmol after 5 days GONTHIER 2003_02
5-(3',4',-dihydroxyphenyl)-γ-valerolactone Not applicable 0.12 g/100 g bw Single dose 8 Detected (unquantified) GONTHIER 2003_03
5-(3',4'-dihydroxyphenyl)-valeric acid Not applicable 0.12 g/100 g bw Single dose 8 Detected (unquantified) GONTHIER 2003_03
0.1 % of diet 5 days 5 0.005 µmol after 5 days GONTHIER 2003_02
5-(3'-Methoxy-4'-hydroxyphenyl)-γ-valerolactone Not applicable 0.12 g/100 g bw Single dose 8 Detected (unquantified) GONTHIER 2003_03
Dihydrocaffeic acid Not applicable 0.12 g/100 g bw Single dose 8 13.6 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 0.05 µmol after 5 days GONTHIER 2003_02
Ferulic acid Not applicable 0.12 g/100 g bw Single dose 8 163.2 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 0.3 µmol after 5 days GONTHIER 2003_02
Hippuric acid Not applicable 0.1 % of diet 5 days 5 30.25 µmol after 5 days GONTHIER 2003_02
0.12 g/100 g bw Single dose 8 70 µmol/L after 8 days GONTHIER 2003_03
m-Coumaric acid Not applicable 0.1 % of diet 5 days 5 4.15 µmol after 5 days GONTHIER 2003_02
p-Coumaric acid Not applicable 0.12 g/100 g bw Single dose 8 28.8 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 0.1 µmol after 5 days GONTHIER 2003_02
Phenylacetic acid Not applicable 0.12 g/100 g bw Single dose 8 2425.6 µg after 8 days GONTHIER 2003_03
Protocatechuic acid Not applicable 0.1 % of diet 5 days 5 0.19 µmol after 5 days GONTHIER 2003_02
Vanillic acid Not applicable 0.12 g/100 g bw Single dose 8 461.6 µg after 8 days GONTHIER 2003_03
0.1 % of diet 5 days 5 5.7 µmol after 5 days GONTHIER 2003_02
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Quercetin Not applicable 25 mg Single dose 10 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 SOLEAS 2001
rat studies
(+)-Catechin Not applicable 172 µmol/kg bw Single dose 5 1.13 µmol after 24 hours 0.19 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
0.2 % of diet 6 weeks 8 Detected (unquantified) FARDET 2008_01
3'-O-Methylcatechin Not applicable 172 µmol/kg bw Single dose 5 0.64 µmol after 24 hours 0.03 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 BABA 2001_02
4-Hydroxyhippuric acid Not applicable 0.2 % of diet 6 weeks 8 Detected (unquantified) FARDET 2008_01
5-(3'-Methoxy-4'-hydroxyphenyl)-γ-valerolactone Not applicable 0.2 % of diet 6 weeks 8 Detected (unquantified) FARDET 2008_01
Hippuric acid Not applicable 0.2 % of diet 6 weeks 8 Detected (unquantified) FARDET 2008_01