Showing all polyphenol metabolites originating from consumption of dietary polyphenol (-)-Catechin Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Quercetin | Not applicable | 25 mg | Single dose | 10 |
|
SOLEAS 2001 | ||||||
| rat studies | ||||||||||||
| (+)-Catechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 8.85 µmol after 24 hours | 66.4 |
|
BABA 2001_02 | ||||
| 0.12 g/100 g bw | Single dose | 8 |
|
1.3 µmol/L after 8 days | GONTHIER 2003_03 | |||||||
| 0.1 % of diet | 5 days | 5 | 37 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3'-O-Methylcatechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 3.6 µmol after 24 hours | 23 |
|
BABA 2001_02 | ||||
| 0.12 g/100 g bw | Single dose | 8 |
|
GONTHIER 2003_03 | ||||||||
| 0.1 % of diet | 5 days | 5 | 43 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3,4-Dihydroxyphenylacetic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 100.8 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.25 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3-Hydroxybenzoic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 864 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 1.25 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3-Hydroxyhippuric acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 1067.2 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 1.45 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3-Hydroxyphenylacetic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 191.2 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.4 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3-Hydroxyphenylpropionic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 6588 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.25 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 3-Hydroxyphenylvaleric acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | Detected (unquantified) | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.23 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 4-Hydroxybenzoic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 711.2 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 2.1 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 4-Hydroxyhippuric acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 716 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 1.9 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 5-(3',4',-dihydroxyphenyl)-γ-valerolactone | Not applicable | 0.12 g/100 g bw | Single dose | 8 | Detected (unquantified) | GONTHIER 2003_03 | ||||||
| 5-(3',4'-dihydroxyphenyl)-valeric acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | Detected (unquantified) | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.005 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| 5-(3'-Methoxy-4'-hydroxyphenyl)-γ-valerolactone | Not applicable | 0.12 g/100 g bw | Single dose | 8 | Detected (unquantified) | GONTHIER 2003_03 | ||||||
| Dihydrocaffeic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 13.6 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.05 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| Ferulic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 163.2 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.3 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| Hippuric acid | Not applicable | 0.1 % of diet | 5 days | 5 | 30.25 µmol after 5 days | GONTHIER 2003_02 | ||||||
| 0.12 g/100 g bw | Single dose | 8 | 70 µmol/L after 8 days | GONTHIER 2003_03 | ||||||||
| m-Coumaric acid | Not applicable | 0.1 % of diet | 5 days | 5 | 4.15 µmol after 5 days | GONTHIER 2003_02 | ||||||
| p-Coumaric acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 28.8 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 0.1 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| Phenylacetic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 2425.6 µg after 8 days | GONTHIER 2003_03 | ||||||
| Protocatechuic acid | Not applicable | 0.1 % of diet | 5 days | 5 | 0.19 µmol after 5 days | GONTHIER 2003_02 | ||||||
| Vanillic acid | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 461.6 µg after 8 days | GONTHIER 2003_03 | ||||||
| 0.1 % of diet | 5 days | 5 | 5.7 µmol after 5 days | GONTHIER 2003_02 | ||||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Quercetin | Not applicable | 25 mg | Single dose | 10 |
|
SOLEAS 2001 | ||||||
| rat studies | ||||||||||||
| (+)-Catechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 1.13 µmol after 24 hours | 0.19 |
|
BABA 2001_02 | ||||
| 0.2 % of diet | 6 weeks | 8 | Detected (unquantified) | FARDET 2008_01 | ||||||||
| 3'-O-Methylcatechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 0.64 µmol after 24 hours | 0.03 |
|
BABA 2001_02 | ||||
| 4-Hydroxyhippuric acid | Not applicable | 0.2 % of diet | 6 weeks | 8 | Detected (unquantified) | FARDET 2008_01 | ||||||
| 5-(3'-Methoxy-4'-hydroxyphenyl)-γ-valerolactone | Not applicable | 0.2 % of diet | 6 weeks | 8 | Detected (unquantified) | FARDET 2008_01 | ||||||
| Hippuric acid | Not applicable | 0.2 % of diet | 6 weeks | 8 | Detected (unquantified) | FARDET 2008_01 | ||||||