Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Hesperetin Food administered
5 mL/kg bw Single dose 16 8.9 7.4 1.05 4.16 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 NIELSEN 2006
  Urine Plasma  
Polyphenol metabolite Composition of the [polyphenol] source Doses
administered
Dose
duration
Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
Hesperetin 3',7-O-diglucuronide Food administered
0 Single dose 16 Detected (unquantified) BREDSDORFF 2010
Hesperetin 3'-O-glucuronide Food administered
0 Single dose 16 49 µmol/L after 7.5 hours BREDSDORFF 2010
Hesperetin 3'-sulfate Food administered
0 Single dose 16 7 µmol/L after 7.5 hours BREDSDORFF 2010
Hesperetin 5,7-O-diglucuronide Food administered
0 Single dose 16 Detected (unquantified) BREDSDORFF 2010
Hesperetin 7-O-glucuronide Food administered
0 Single dose 16 5 µmol/L after 7.5 hours BREDSDORFF 2010
Naringenin 4'-O-glucuronide Food administered
0 Single dose 16 0.3 µmol/L after 7.5 hours BREDSDORFF 2010
250 mL Single dose 8 0.9 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Detected (unquantified) MULLEN 2008_01
250 mL Single dose 8 8.3 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 MULLEN 2008_01
250 mL Single dose 8 0.7 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Detected (unquantified) MULLEN 2008_01
250 mL Single dose 8 8.6 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 MULLEN 2008_01
Naringenin 7-O-glucuronide Food administered
0 Single dose 16 0.2 µmol/L after 7.5 hours BREDSDORFF 2010
250 mL Single dose 8 8.5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Detected (unquantified) MULLEN 2008_01
250 mL Single dose 8 6.6 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 Detected (unquantified) MULLEN 2008_01
3-Hydroxy-3-(3-hydroxyphenyl)propionic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
3-Hydroxy-4-methoxyphenyllactic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
3-Hydroxyhippuric acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
3-Hydroxyphenylacetic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
4-Hydroxybenzoic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
4-Hydroxyphenylacetic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
Dihydroferulic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
Hippuric acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009
Homovanillic acid Food administered
250 mL Single dose 5 Graph a9d716975d07e4a7e41abb50e7f45e82a5a61800f83ed43664b0781ff2caee59 ROOWI 2009