Showing all polyphenol metabolites originating from consumption of Orange [Blond], pure juice, fortified with hesperidin Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Hesperetin |
Food administered |
5 mL/kg bw | Single dose | 16 | 8.9 | 7.4 | 1.05 | 4.16 |
|
NIELSEN 2006 | ||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| Hesperetin 3',7-O-diglucuronide |
Food administered |
0 | Single dose | 16 | Detected (unquantified) | BREDSDORFF 2010 | ||||||
| Hesperetin 3'-O-glucuronide |
Food administered |
0 | Single dose | 16 | 49 µmol/L after 7.5 hours | BREDSDORFF 2010 | ||||||
| Hesperetin 3'-sulfate |
Food administered |
0 | Single dose | 16 | 7 µmol/L after 7.5 hours | BREDSDORFF 2010 | ||||||
| Hesperetin 5,7-O-diglucuronide |
Food administered |
0 | Single dose | 16 | Detected (unquantified) | BREDSDORFF 2010 | ||||||
| Hesperetin 7-O-glucuronide |
Food administered |
0 | Single dose | 16 | 5 µmol/L after 7.5 hours | BREDSDORFF 2010 | ||||||
| Naringenin 4'-O-glucuronide |
Food administered |
0 | Single dose | 16 | 0.3 µmol/L after 7.5 hours | BREDSDORFF 2010 | ||||||
| 250 mL | Single dose | 8 | 0.9 |
|
Detected (unquantified) | MULLEN 2008_01 | ||||||
| 250 mL | Single dose | 8 | 8.3 |
|
MULLEN 2008_01 | |||||||
| 250 mL | Single dose | 8 | 0.7 |
|
Detected (unquantified) | MULLEN 2008_01 | ||||||
| 250 mL | Single dose | 8 | 8.6 |
|
MULLEN 2008_01 | |||||||
| Naringenin 7-O-glucuronide |
Food administered |
0 | Single dose | 16 | 0.2 µmol/L after 7.5 hours | BREDSDORFF 2010 | ||||||
| 250 mL | Single dose | 8 | 8.5 |
|
Detected (unquantified) | MULLEN 2008_01 | ||||||
| 250 mL | Single dose | 8 | 6.6 |
|
Detected (unquantified) | MULLEN 2008_01 | ||||||
| 3-Hydroxy-3-(3-hydroxyphenyl)propionic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| 3-Hydroxy-4-methoxyphenyllactic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| 3-Hydroxyhippuric acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 3-Hydroxyphenylacetic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| 4-Hydroxybenzoic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| 4-Hydroxyphenylacetic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| Dihydroferulic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| Hippuric acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| 250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||||
| Homovanillic acid |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||