Showing experiments where Enterolactone has been detected in biofluids Metabolism

  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
cocoa powder Food administered
Generic food 		10 g Single dose 9 3.6 µmol after 24 hours ITO 2005
cocoa powder in water Food administered
Generic food 		40 g Single dose 21 0.11 nmol/mg creatinine after 24 hours URPI-SARDA 2009_01
flaxseed powder Generic food 10 g/day 90 days 18 2501.1 µmol after 90 days LAMPE 1994
grape skin extract Food administered
 18 g Single dose 9 6.7 µmol after 24 hours ITO 2005
grapefruit juice Food administered
 430 mL Single dose 9 1.4 µmol after 12 hours ITO 2005
green tea extract Food administered
 0.3 g Single dose 9 3 µmol after 24 hours ITO 2005
ground flaxseed Food administered
Generic food 		10 g/day 7 weeks 31 56247 nmol/day after 7 weeks HUTCHINS 2000
high-isoflavone burger Food administered
 1 burger/day 17 days 23 2804 nmol/day after 17 days 27 nmol/L after 17 days ROWLAND 2000
instant coffee Food administered
 4 g Single dose 9 2.8 µmol after 24 hours ITO 2005
isoflavones from soy protein powder Not applicable 2 mg/day 93 days 18 3820 nmol after 24 hours XU 2000
isoflavones from soy protein powder Not applicable 0.11 mg/day 93 days 18 1382 nmol after 24 hours XU 2000
isoflavones from soy protein powder Not applicable 1 mg/day 93 days 18 2404 nmol after 24 hours XU 2000
linseed Generic food 25 g/day 6 weeks 23 MORTON 1994
low-isoflavone burger Food administered
 1 burger/day 17 days 21 3898 nmol/day after 17 days 31 nmol/L after 17 days ROWLAND 2000
orange juice Food administered
 550 g Single dose 9 1.8 µmol after 12 hours ITO 2005
processed flaxseed incorporated into bread Food administered
Generic food 		25 g 7 days 9 9.77 µmol/24h after 7 days NESBITT 1999
processed flaxseed incorporated into muffin Food administered
Generic food 		25 g 7 days 9 13.45 µmol/24h after 7 days NESBITT 1999
raw ground flaxseed Food administered
Generic food 		5 g Single dose 9 1.81 µmol/24h after 7 days NESBITT 1999
raw ground flaxseed Food administered
Generic food 		15 g 7 days 9 7.28 µmol/24h after 7 days NESBITT 1999
raw ground flaxseed Food administered
Generic food 		25 g 8 days 9 10.86 µmol/24h after 7 days Graph NESBITT 1999
red clover seeds Not applicable 10 g/day 6 weeks 4 MORTON 1994
soy bars Food administered
 3 bars/day 14 days 6 Detected (unquantified) HEINONEN 1999
soybean pieces Food administered
Generic food 		125 g/day 9 days 17 2853 nmol after 9 days HUTCHINS 1995_01
steam-treated soya flour Generic food 45 g/day 6 weeks 4 MORTON 1994
tempeh Food administered
Generic food 		112 g/day 9 days 17 2952 nmol after 9 days HUTCHINS 1995_01
rat studies
3H-secoisolariciresinol diglycoside Not applicable 3.7 kBq/g bw Single dose 12 6 RICKARD 2000
7-hydroxymatairesinol Not applicable 25 mg/kg bw Single dose 11 27.7 nmol after 24 hours SMEDS 2004
7-hydroxymatairesinol Not applicable 25 mg/kg bw Single dose 6 59 18.2 µg after 24 hours SAARINEN 2002
7-hydroxymatairesinol Not applicable 25 mg/kg bw 10 days 11 1570 nmol after 24 hours SMEDS 2004
corn oil (control) Not applicable 1 mL Single dose 2 Detected (unquantified) NIEMEYER 2000
enterodiol in corn oil Not applicable 2 mg Single dose 2 Detected (unquantified) NIEMEYER 2000
enterolactone Not applicable 25 mg/kg bw Single dose 6 17 24.5 µg after 24 hours SAARINEN 2002
enterolactone in corn oil Not applicable 2 mg Single dose 2 Detected (unquantified) NIEMEYER 2000
lariciresinol Not applicable 25 mg/kg bw Single dose 11 33.2 nmol after 24 hours SMEDS 2004
lariciresinol Not applicable 25 mg/kg bw 10 days 11 896 nmol after 24 hours SMEDS 2004
matairesinol Not applicable 25 mg/kg bw Single dose 7 50 nmol after 24 hours SMEDS 2004
matairesinol Not applicable 25 mg/kg bw Single dose 6 76 54.7 µg after 24 hours SAARINEN 2002
matairesinol Not applicable 25 mg/kg bw 10 days 7 950 nmol after 24 hours SMEDS 2004
natural cocoa Food administered
 10 % of diet 2 weeks 7 2.05 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
natural cocoa powder Food administered
 4.8 g/kg bw/day 2 weeks 7 0.26 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
secoisolariciresinol Not applicable 25 mg/kg bw Single dose 11 137 nmol after 24 hours SMEDS 2004
secoisolariciresinol Not applicable 25 mg/kg bw Single dose 6 58 40.9 µg after 24 hours SAARINEN 2002
secoisolariciresinol Not applicable 25 mg/kg bw 10 days 11 1328 nmol after 24 hours SMEDS 2004
secoisolariciresinol diglycoside Not applicable 25 mg/kg bw Single dose 6 311 µg after 24 hours SAARINEN 2002
secoisolariciresinol diglycoside Not applicable 1.5 mg/day 10 days 12 9.5 RICKARD 2000
sesaminol triglucoside Not applicable 1500 mg/kg bw 4 days 30 1.2 µmol/mL after 12 hours 5.5 µmol/mL after 12 hours JAN 2009
shredded flaxseed Generic food 5 % of diet 7 days 2 Detected (unquantified) NIEMEYER 2000
mouse studies
flaxseed Generic food 10 % of diet 10 weeks 24 Graph KINNIRY 2006