Showing experiments where Procyanidin dimer B2 has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| cocoa in 300 mL water |
Food administered Generic food |
0.37 g/kg bw | Single dose | 5 |
|
HOLT 2002 | ||||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 | 0.2 nmol/mg creatinine after 24 hours | URPI-SARDA 2009_01 | ||||||
| rat studies | ||||||||||||
| natural cocoa |
Food administered |
10 % of diet | 2 weeks | 7 | 3.1 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| natural cocoa powder |
Food administered |
4.8 g/kg bw/day | 2 weeks | 7 | 0.49 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| procyanidin B2 | Not applicable | 50 mg/kg bw | Single dose | 5 | 0.5 | 0.5 |
|
BABA 2002 | ||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| grape seed extract | Not applicable | 1 g/kg bw | Single dose | 4 | 0.3 | 4.2 µg after 4 hours | TSANG 2005 | |||||
| procyanidin B2 | Not applicable | 50 mg/kg bw | Single dose | 5 | 0.34 | 83 nmol after 18 hours | BABA 2002 | |||||