Showing experiments where Hesperetin has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| blood orange juice |
Food administered Generic food |
150 mL | Single dose | 7 | 5.3 | 0.14 | 1.1 | 195.5 |
|
GARDANA 2007_02 | ||
| flavanone extract diluted in water | Generic food | 400 mL | Single dose | 10 | 8.9 | 28.3 µmol after 48 hours | 6.3 | 1.48 | 4145.1 | VALLEJO 2010 | ||
| flavanone extract-enriched orange juice | Generic food | 400 mL | Single dose | 10 | 4.6 | 30.8 µmol after 48 hours | 7.3 | 1.15 | 4434.4 | VALLEJO 2010 | ||
| fresh orange segments |
Food administered Generic food |
150 g | Single dose | 20 | 4.53 | 7 | 0.09 | 376 |
|
BRETT 2009 | ||
| green tea extract |
Food administered |
0.3 g | Single dose | 9 | 0.5 µmol after 24 hours | ITO 2005 | ||||||
| juice mix | Not applicable | 6.3 mL/kg bw | Single dose | 10 | 14.2 |
|
4.9 | 0.18 | 2.13 |
|
ISHII 2000 | |
| orange juice |
Food administered |
550 g | Single dose | 9 | 16.6 µmol after 12 hours | ITO 2005 | ||||||
| orange juice | Generic food | 400 mL | Single dose | 10 | 1.7 | 5.7 µmol after 48 hours | 6.4 | 0.36 | 945.6 | VALLEJO 2010 | ||
| orange juice | Generic food | 5 mL/kg bw | Single dose | 16 | 4.06 | 7 | 0.48 | 1.16 |
|
NIELSEN 2006 | ||
| orange juice | Generic food | 400 mL | Single dose | 10 | 5.4 | 9 µmol after 48 hours | VALLEJO 2010 | |||||
| orange juice | Generic food | 300 g | Single dose | 129 | 3.9 | BRETT 2009 | ||||||
| orange juice | Generic food | 300 g | Single dose | 20 | 4.63 | 6.2 | 0.1 | 346 |
|
BRETT 2009 | ||
| orange juice | Not applicable | 236 mL/day | 22 days | 13 |
|
|
FRANKE 2005 | |||||
| orange juice fortified with hesperidin |
Food administered |
5 mL/kg bw | Single dose | 16 | 8.9 | 7.4 | 1.05 | 4.16 |
|
NIELSEN 2006 | ||
| orange juice treated with hesperidinase |
Food administered |
5 mL/kg bw | Single dose | 16 | 14.4 | 0.6 | 2.6 | 3.45 |
|
NIELSEN 2006 | ||
| pulp-enriched orange juice | Generic food | 400 mL | Single dose | 10 | 4.7 | 4.7 µmol after 48 hours | 6 | 0.15 | 503.6 | VALLEJO 2010 | ||
| rat studies | ||||||||||||
| eriocitrin | Not applicable | 75 µmol/kg bw | Single dose | 5 | 50 ng/mL after 4 hours | MIYAKE 2000 | ||||||
| eriocitrin | Not applicable | 50 µmol/kg bw | Single dose | 4 | 20 µg after 24 hours | MIYAKE 2000 | ||||||
| hesperidin | Not applicable | 50 mg/kg bw | Single dose | 5 |
|
MATSUMOTO 2004 | ||||||
| naringin | Not applicable | 0.5 % of diet | 7 days | 6 | 47 nmol after 24 hours | 0.23 µmol/L after 24 hours | SILBERBERG 2006 | |||||
| pig studies | ||||||||||||
| extract of unfermented Cyclopia genistoides | Not applicable | 75 g/day | 11 days | 3 | Detected (unquantified) | BOCK 2008 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| eriocitrin | Not applicable | 50 µmol/kg bw | Single dose | 4 | 25 µg after 24 hours | MIYAKE 2000 | ||||||