Showing experiments where Homovanillic acid has been detected in biofluids Metabolism

  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
5-caffeoylquinic acid Not applicable 2 g/day 7 days 20 41 µmol/24h after 1 weeks OLTHOF 2003
almond skin extract capsules Food administered
 10 capsules Single dose 2 URPI-SARDA 2009_02
black tea solids Food administered
 4 g/day 7 days 20 54 µmol/24h after 1 weeks OLTHOF 2003
citric acid in water Not applicable 0.5 g/day 7 days 20 52 µmol/24h after 1 weeks OLTHOF 2003
cocoa powder in skimmed milk Food administered
Generic food 		40 g/day 4 weeks 42 34.82 µmol after 24 hours URPI-SARDA 2009_03
cocoa powder in water Food administered
Generic food 		40 g Single dose 21 1.54 nmol/mg creatinine after 24 hours URPI-SARDA 2009_01
phenol-poor olive oil with 13.3 mg hydroxytyrosol Food administered
 50 mL Single dose 6 2380 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 19.2 mg hydroxytyrosol Food administered
 50 mL Single dose 6 2837 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 23.2 mg hydroxytyrosol Food administered
 50 mL Single dose 6 3759 µg after 24 hours CARUSO 2001
phenol-poor olive oil with 7 mg hydroxytyrosol Food administered
 50 mL Single dose 6 1027 µg after 24 hours CARUSO 2001
quercetin 3-O-rutinoside Not applicable 440 mg/day 7 days 20 103 µmol/24h after 1 weeks OLTHOF 2003
rat studies
natural cocoa Food administered
 10 % of diet 2 weeks 7 11.27 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
natural cocoa powder Food administered
 4.8 g/kg bw/day 2 weeks 7 5.92 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
radiolabelled hydroxytyrosol in olive oil Not applicable 0 Single dose 5 Graph TUCK 2002
red wine and red grape extract capsules Food administered
 1 capsules/day 28 days 26 Detected (unquantified) GRUN 2008
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
green tea Food administered
Generic food 		300 mL Single dose 5 Graph ROOWI 2010
orange juice fortified with hesperidin Food administered
 250 mL Single dose 5 Graph ROOWI 2009
tomato juice enriched with rutin Food administered
 300 mL Single dose 6 Graph JAGANATH 2006