Showing all polyphenol metabolites originating from consumption of Grape, seed, polyphenol extract Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| (+)-Catechin |
Food administered |
600 mg/kg bw/day | 3 days | 8 | Detected (unquantified) | Detected (unquantified) | PRASAIN 2009 | |||||
| 100 mg/kg bw | Single dose | 8 | 1.8 | 1.34 | 606.1 |
|
FERRUZZI 2009 | |||||
| (-)-Epicatechin |
Food administered |
600 mg/kg bw/day | 3 days | 8 | Detected (unquantified) | Detected (unquantified) | PRASAIN 2009 | |||||
| 100 mg/kg bw | Single dose | 8 | 1.5 | 1.9 | 1197.9 |
|
FERRUZZI 2009 | |||||
| 3'-O-Methylcatechin |
Food administered |
100 mg/kg bw | Single dose | 8 | 1.4 | 0.24 | 184.8 |
|
FERRUZZI 2009 | |||
| 3'-O-Methylepicatechin |
Food administered |
100 mg/kg bw | Single dose | 8 | 1.5 | 0.34 | 266.6 |
|
FERRUZZI 2009 | |||
| 4-O-Methylgallic acid |
Food administered |
150 mg/kg bw | Single dose | 8 | 0.9 | 0.4 | 162.4 |
|
FERRUZZI 2009 | |||
| Gallic acid |
Food administered |
100 mg/kg bw | Single dose | 8 | 1.3 | 1.4 | 673.1 |
|
FERRUZZI 2009 | |||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Polyphenol metabolite | Composition of the [polyphenol] source | Doses administered |
Dose duration |
Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| Procyanidin dimer B1 | Not applicable | 1 g/kg bw | Single dose | 4 | 0.5 | 7.5 µg after 4 hours | TSANG 2005 | |||||
| Procyanidin dimer B2 | Not applicable | 1 g/kg bw | Single dose | 4 | 0.3 | 4.2 µg after 4 hours | TSANG 2005 | |||||
| Procyanidin dimer B3 | Not applicable | 1 g/kg bw | Single dose | 4 | 1 | 6.4 µg after 4 hours | TSANG 2005 | |||||
| Procyanidin dimer B4 | Not applicable | 1 g/kg bw | Single dose | 4 | 0.4 | 3 µg after 4 hours | TSANG 2005 | |||||
| Procyanidin trimer C2 | Not applicable | 1 g/kg bw | Single dose | 4 | 4.3 | 13 µg after 4 hours | TSANG 2005 | |||||