Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
5-caffeoylquinic acid Not applicable 2 g/day 7 days 20 97 µmol/24h after 1 weeks OLTHOF 2003
almond skin extract capsules Food administered
10 capsules Single dose 2 URPI-SARDA 2009_02
cocoa powder in skimmed milk Food administered
Generic food
40 g/day 4 weeks 42 2.92 µmol after 24 hours 0.2 µmol/L after 24 hours URPI-SARDA 2009_03
cocoa powder in water Food administered
Generic food
40 g Single dose 21 0.79 nmol/mg creatinine after 24 hours URPI-SARDA 2009_01
cocoa powder in water Food administered
Generic food
40 g Single dose 21 Graph URPI-SARDA 2010
cocoa powder in whole milk Food administered
Generic food
40 g Single dose 21 Graph URPI-SARDA 2010
dark chocolate Generic food 80 g Single dose 11 Graph RIOS 2003
epicatechin Not applicable 200 mg Single dose 12 Graph LOKE 2009
epigallocatechin gallate Not applicable 200 mg Single dose 12 Graph LOKE 2009
instant coffee in hot water Food administered
4 g Single dose 1 8 0.3 Graph GUY 2009
quercetin Not applicable 200 mg Single dose 12 Graph Graph LOKE 2009
rat studies
5-caffeoylquinic acid Not applicable 250 µmol/day 8 days 8 Graph GONTHIER 2003_01
caffeic acid Not applicable 250 µmol/day 8 days 8 1.28 µmol after 8 days GONTHIER 2003_01
catechin Not applicable 0.12 g/100 g bw Single dose 8 13.6 µg after 8 days GONTHIER 2003_03
catechin Not applicable 0.1 % of diet 5 days 5 0.05 µmol after 5 days GONTHIER 2003_02
natural cocoa Food administered
10 % of diet 2 weeks 7 0.93 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
natural cocoa powder Food administered
4.8 g/kg bw/day 2 weeks 7 0.39 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
procyanidin dimer B3 Not applicable 0.1 % of diet 5 days 5 0.02 µmol after 5 days GONTHIER 2003_02
quinic acid Not applicable 250 µmol/day 8 days 8 0.16 µmol after 8 days GONTHIER 2003_01
wine powder Food administered
0.5 g/100 g bw Single dose 8 37.6 µg after 8 days GONTHIER 2003_03
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
instant coffee Food administered
200 mL Single dose 11 Detected (unquantified) 5.2 0.04 1 142 Graph STALMACH 2009_02
rat studies
dihydrocaffeic acid Not applicable 100 µmol/kg bw Single dose 0 Detected (unquantified) POQUET 2008