Showing experiments where Caffeic acid has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| 5-caffeoylquinic acid | Not applicable | 2 g/day | 7 days | 20 | 56 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| almond skin extract capsules |
Food administered |
10 capsules | Single dose | 2 | URPI-SARDA 2009_02 | |||||||
| cocoa powder |
Food administered Generic food |
10 g | Single dose | 9 | 0.4 µmol after 24 hours | ITO 2005 | ||||||
| cocoa powder in skimmed milk |
Food administered Generic food |
40 g/day | 4 weeks | 42 | 0.07 µmol after 24 hours | 0.08 µmol/L after 24 hours | URPI-SARDA 2009_03 | |||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 | 0.39 nmol/mg creatinine after 24 hours | URPI-SARDA 2009_01 | ||||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 |
|
URPI-SARDA 2010 | ||||||
| cocoa powder in whole milk |
Food administered Generic food |
40 g | Single dose | 21 |
|
URPI-SARDA 2010 | ||||||
| dealcoholized red wine equivalents | Not applicable | 5 mL/kg bw | Single dose | 12 | 2 | 0.09 |
|
CACCETTA 2000 | ||||
| grape skin extract |
Food administered |
18 g | Single dose | 9 | 0.7 µmol after 24 hours | ITO 2005 | ||||||
| grapefruit juice |
Food administered |
430 mL | Single dose | 9 | 0.4 µmol after 12 hours | ITO 2005 | ||||||
| green tea extract |
Food administered |
0.3 g | Single dose | 9 | 0.3 µmol after 24 hours | ITO 2005 | ||||||
| instant coffee |
Food administered |
4 g | Single dose | 9 | 2.1 µmol after 24 hours | ITO 2005 | ||||||
| instant coffee in hot water |
Food administered |
4 g | Single dose | 1 | 1.5 | 0.06 |
|
GUY 2009 | ||||
| one tablet of perilla extract |
Food administered |
1 tablet | Single dose | 6 | 0.96 |
|
Detected (unquantified) | BABA 2005 | ||||
| orange juice |
Food administered |
550 g | Single dose | 9 | 0.2 µmol after 12 hours | ITO 2005 | ||||||
| phenol-stripped red wine equivalents |
Food administered |
5 mL/kg bw | Single dose | 12 |
|
CACCETTA 2000 | ||||||
| red wine equivalents |
Food administered Generic food |
5 mL/kg bw | Single dose | 12 | 3 | 0.08 |
|
CACCETTA 2000 | ||||
| rat studies | ||||||||||||
| 5-caffeoylquinic acid | Not applicable | 250 µmol/day | 8 days | 8 |
|
GONTHIER 2003_01 | ||||||
| caffeic acid | Not applicable | 250 µmol/day | 8 days | 8 | 181 µmol after 8 days | 41.3 µmol/L after 8 days | GONTHIER 2003_01 | |||||
| cranberry powder diet |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.89 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| eriocitrin | Not applicable | 50 µmol/kg bw | Single dose | 4 | 0.5 µg after 24 hours | MIYAKE 2000 | ||||||
| natural cocoa |
Food administered |
10 % of diet | 2 weeks | 7 | 1.26 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| natural cocoa powder |
Food administered |
4.8 g/kg bw/day | 2 weeks | 7 | 0.04 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| rosmarinic acid in deoinized water | Not applicable | 50 mg/kg bw | Single dose | 5 | 1.06 |
|
BABA 2004 | |||||
| wine powder |
Food administered |
0.5 g/100 g bw | Single dose | 8 | 160 µg after 8 days | GONTHIER 2003_03 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| rat studies | ||||||||||||
| caffeic acid | Not applicable | 40 mg/kg bw | Single dose | 8 | Detected (unquantified) | Detected (unquantified) | ZHANG 2008_02 | |||||
| cranberry powder diet |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 0.04 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| eriocitrin | Not applicable | 75 µmol/kg bw | Single dose | 5 | 3.4 ng/mL after 4 hours | MIYAKE 2000 | ||||||
| eriocitrin | Not applicable | 50 µmol/kg bw | Single dose | 4 | 2 µg after 24 hours | MIYAKE 2000 | ||||||
| shuangdan granules | Not applicable | 12 g/100 g bw/day | 1 days | 6 | Detected (unquantified) | PAN 2006 | ||||||