Showing experiments where (-)-Epicatechin has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| cocoa in 300 mL water |
Food administered Generic food |
0.37 g/kg bw | Single dose | 5 |
|
HOLT 2002 | ||||||
| cocoa powder |
Food administered Generic food |
10 g | Single dose | 9 | 4.3 µmol after 24 hours | ITO 2005 | ||||||
| cocoa powder in skimmed milk |
Food administered Generic food |
40 g/day | 4 weeks | 42 | 0.24 µmol after 24 hours | URPI-SARDA 2009_03 | ||||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 | 0.53 nmol/mg creatinine after 24 hours | URPI-SARDA 2009_01 | ||||||
| epicatechin | Not applicable | 200 mg | Single dose | 12 |
|
|
LOKE 2009 | |||||
| green tea extract |
Food administered |
0.3 g | Single dose | 9 | 2.1 µmol after 24 hours | ITO 2005 | ||||||
| green tea powder in hot water |
Food administered |
1.2 g | Single dose | 5 |
|
LI 2000 | ||||||
| green tea powder in hot water |
Food administered |
2.4 g | Single dose | 1 | 17.03 µmol after 6 days | LI 2000 | ||||||
| theaflavins in hot water |
Food administered |
700 mg | Single dose | 2 | Detected (unquantified) | MULDER 2001 | ||||||
| rat studies | ||||||||||||
| (-)-epicatechin | Not applicable | 10 mg/kg bw | Single dose | 5 |
|
BABA 2001_01 | ||||||
| cocoa powder |
Food administered Generic food |
1500 mg/kg bw | Single dose | 5 |
|
BABA 2001_01 | ||||||
| cocoa powder |
Food administered Generic food |
1 g/kg bw | Single dose | 5 | 1 | 9 |
|
BABA 2000 | ||||
| epicatechin | Not applicable | 100 mg/kg bw | Single dose | 9 | 50 µmol/L after 1 days | ABD EL MOHSEN 2002 | ||||||
| epicatechin | Not applicable | 100 mg/kg bw | Single dose | 9 | 51 µmol/L after 10 days | ABD EL MOHSEN 2002 | ||||||
| epicatechin | Not applicable | 100 mg/kg bw | Single dose | 9 | 54 µmol/L after 5 days | ABD EL MOHSEN 2002 | ||||||
| epicatechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 16.6 µmol after 24 hours | 78.3 |
|
BABA 2001_02 | ||||
| grape seed extract in aqueous solution |
Food administered |
600 mg/kg bw/day | 3 days | 8 | Detected (unquantified) | Detected (unquantified) | PRASAIN 2009 | |||||
| grape seed polyphenolic extract |
Food administered |
100 mg/kg bw | Single dose | 8 | 1.5 | 1.9 | 1197.9 |
|
FERRUZZI 2009 | |||
| mixture of catechin and epicatechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 9.43 µmol after 24 hours | 76.5 |
|
BABA 2001_02 | ||||
| natural cocoa |
Food administered |
10 % of diet | 2 weeks | 7 | 36.62 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| natural cocoa powder |
Food administered |
4.8 g/kg bw/day | 2 weeks | 7 | 5.49 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| procyanidin B2 | Not applicable | 50 mg/kg bw | Single dose | 5 | 0.5 | 0.25 |
|
BABA 2002 | ||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| (-)-epicatechin | Not applicable | 1 g | Single dose | 4 | 443.6 ng/mL after 1 hours | NATSUME 2003 | ||||||
| green tea | Not applicable | 1.2 g | Single dose | 5 | Detected (unquantified) | LI 2001 | ||||||
| rat studies | ||||||||||||
| (-)-epicatechin | Not applicable | 10 mg/kg bw | Single dose | 5 | 1231 nmol after 18 hours |
|
BABA 2001_01 | |||||
| cocoa powder |
Food administered Generic food |
1 g/kg bw | Single dose | 5 | 0.5 | 0.5 |
|
BABA 2000 | ||||
| cocoa powder |
Food administered Generic food |
1500 mg/kg bw | Single dose | 5 | 1067 nmol after 18 hours |
|
BABA 2001_01 | |||||
| epicatechin | Not applicable | 100 mg/kg bw | Single dose | 9 | 4.3 µmol/L after 1 days | ABD EL MOHSEN 2002 | ||||||
| epicatechin | Not applicable | 100 mg/kg bw | Single dose | 9 | 3.7 µmol/L after 10 days | ABD EL MOHSEN 2002 | ||||||
| epicatechin | Not applicable | 100 mg/kg bw | Single dose | 9 | 5 µmol/L after 5 days | ABD EL MOHSEN 2002 | ||||||
| epicatechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 5.23 µmol after 24 hours | 0.87 |
|
BABA 2001_02 | ||||
| mixture of catechin and epicatechin | Not applicable | 172 µmol/kg bw | Single dose | 5 | 5.54 µmol after 24 hours | 0.82 |
|
BABA 2001_02 | ||||
| procyanidin B2 | Not applicable | 50 mg/kg bw | Single dose | 5 | 0.02 | 12.5 nmol after 18 hours | BABA 2002 | |||||
| procyanidin-rich extract | Not applicable | 1 g/kg bw | Single dose | 3 | 1.28 µmol/L after 2 hours | SERRA 2009 | ||||||