Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
cocoa in 300 mL water Food administered
Generic food
0.37 g/kg bw Single dose 5 Graph HOLT 2002
cocoa powder Food administered
Generic food
10 g Single dose 9 4.3 µmol after 24 hours ITO 2005
cocoa powder in skimmed milk Food administered
Generic food
40 g/day 4 weeks 42 0.24 µmol after 24 hours URPI-SARDA 2009_03
cocoa powder in water Food administered
Generic food
40 g Single dose 21 0.53 nmol/mg creatinine after 24 hours URPI-SARDA 2009_01
epicatechin Not applicable 200 mg Single dose 12 Graph Graph LOKE 2009
green tea extract Food administered
0.3 g Single dose 9 2.1 µmol after 24 hours ITO 2005
green tea powder in hot water Food administered
1.2 g Single dose 5 Graph LI 2000
green tea powder in hot water Food administered
2.4 g Single dose 1 17.03 µmol after 6 days LI 2000
theaflavins in hot water Food administered
700 mg Single dose 2 Detected (unquantified) MULDER 2001
rat studies
(-)-epicatechin Not applicable 10 mg/kg bw Single dose 5 Graph BABA 2001_01
cocoa powder Food administered
Generic food
1500 mg/kg bw Single dose 5 Graph BABA 2001_01
cocoa powder Food administered
Generic food
1 g/kg bw Single dose 5 1 9 Graph BABA 2000
epicatechin Not applicable 100 mg/kg bw Single dose 9 50 µmol/L after 1 days ABD EL MOHSEN 2002
epicatechin Not applicable 100 mg/kg bw Single dose 9 51 µmol/L after 10 days ABD EL MOHSEN 2002
epicatechin Not applicable 100 mg/kg bw Single dose 9 54 µmol/L after 5 days ABD EL MOHSEN 2002
epicatechin Not applicable 172 µmol/kg bw Single dose 5 16.6 µmol after 24 hours 78.3 Graph BABA 2001_02
grape seed extract in aqueous solution Food administered
600 mg/kg bw/day 3 days 8 Detected (unquantified) Detected (unquantified) PRASAIN 2009
grape seed polyphenolic extract Food administered
100 mg/kg bw Single dose 8 1.5 1.9 1197.9 Graph FERRUZZI 2009
mixture of catechin and epicatechin Not applicable 172 µmol/kg bw Single dose 5 9.43 µmol after 24 hours 76.5 Graph BABA 2001_02
natural cocoa Food administered
10 % of diet 2 weeks 7 36.62 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
natural cocoa powder Food administered
4.8 g/kg bw/day 2 weeks 7 5.49 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
procyanidin B2 Not applicable 50 mg/kg bw Single dose 5 0.5 0.25 Graph BABA 2002
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
(-)-epicatechin Not applicable 1 g Single dose 4 443.6 ng/mL after 1 hours NATSUME 2003
green tea Not applicable 1.2 g Single dose 5 Detected (unquantified) LI 2001
rat studies
(-)-epicatechin Not applicable 10 mg/kg bw Single dose 5 1231 nmol after 18 hours Graph BABA 2001_01
cocoa powder Food administered
Generic food
1 g/kg bw Single dose 5 0.5 0.5 Graph BABA 2000
cocoa powder Food administered
Generic food
1500 mg/kg bw Single dose 5 1067 nmol after 18 hours Graph BABA 2001_01
epicatechin Not applicable 100 mg/kg bw Single dose 9 4.3 µmol/L after 1 days ABD EL MOHSEN 2002
epicatechin Not applicable 100 mg/kg bw Single dose 9 3.7 µmol/L after 10 days ABD EL MOHSEN 2002
epicatechin Not applicable 100 mg/kg bw Single dose 9 5 µmol/L after 5 days ABD EL MOHSEN 2002
epicatechin Not applicable 172 µmol/kg bw Single dose 5 5.23 µmol after 24 hours 0.87 Graph BABA 2001_02
mixture of catechin and epicatechin Not applicable 172 µmol/kg bw Single dose 5 5.54 µmol after 24 hours 0.82 Graph BABA 2001_02
procyanidin B2 Not applicable 50 mg/kg bw Single dose 5 0.02 12.5 nmol after 18 hours BABA 2002
procyanidin-rich extract Not applicable 1 g/kg bw Single dose 3 1.28 µmol/L after 2 hours SERRA 2009