Showing experiments where Naringenin has been detected in biofluids Metabolism

  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
alpha-rhamnosidase treated orange juice Food administered
 0 Single dose 16 47 1.63 0.77 70 Graph BREDSDORFF 2010
blood orange juice Food administered
Generic food 		150 mL Single dose 7 5 0.06 1.3 53.9 Graph GARDANA 2007_02
cocoa powder Food administered
Generic food 		10 g Single dose 9 0.3 µmol after 24 hours ITO 2005
cooked cherry tomatoes Food administered
 500 g Single dose 5 Graph BUGIANESI 2004
flavanone extract diluted in water Generic food 400 mL Single dose 10 5.4 18.9 µmol after 48 hours 6.4 0.44 961.1 VALLEJO 2010
flavanone extract-enriched orange juice Generic food 400 mL Single dose 10 1 18.7 µmol after 48 hours 5.9 0.53 1464.8 VALLEJO 2010
Florida-grown grapefruit Not applicable 1 fruits/day 28 days 4 Detected (unquantified) Detected (unquantified) AMEER 1996
fresh cherry tomatoes Food administered
Generic food 		500 g Single dose 5 2 0.06 Graph BUGIANESI 2004
fresh orange segments Food administered
Generic food 		150 g Single dose 20 12.5 5.88 0.08 230 Graph BRETT 2009
grape skin extract Food administered
 18 g Single dose 9 0.3 µmol after 24 hours ITO 2005
grapefruit juice Food administered
 430 mL Single dose 9 24.7 µmol after 12 hours ITO 2005
green tea extract Food administered
 0.3 g Single dose 9 0.5 µmol after 24 hours ITO 2005
instant coffee Food administered
 4 g Single dose 9 0 µmol after 24 hours ITO 2005
juice mix Not applicable 6.3 mL/kg bw Single dose 10 22.6 Graph Graph ISHII 2000
naringin Not applicable 500 mg Single dose 1 4.84 Detected (unquantified) AMEER 1996
naringin powder Not applicable 500 mg Single dose 6 0.38 Graph ISHII 2000
orange juice Food administered
 550 g Single dose 9 8.4 µmol after 12 hours ITO 2005
orange juice Generic food 400 mL Single dose 10 0.7 2.6 µmol after 48 hours 5.7 0.44 735.2 VALLEJO 2010
orange juice Generic food 400 mL Single dose 10 2.6 4.8 µmol after 48 hours VALLEJO 2010
orange juice Food administered
Generic food 		0 Single dose 16 7 5.18 0.12 18 Graph BREDSDORFF 2010
orange juice Generic food 300 g Single dose 129 14.5 BRETT 2009
orange juice Generic food 300 g Single dose 20 10.2 4.46 0.05 176 Graph BRETT 2009
orange juice Not applicable 236 mL/day 22 days 13 Graph Graph FRANKE 2005
pulp-enriched orange juice Generic food 400 mL Single dose 10 0.5 2.3 µmol after 48 hours 5 0.06 200.6 VALLEJO 2010
rat studies
naringenin Not applicable 270 mg/kg bw Single dose 10 2 161.25 10.51 463107.43 Graph MA 2006
naringin Not applicable 0.5 % of diet 7 days 6 5900 nmol after 24 hours 17 µmol/L after 24 hours SILBERBERG 2006
naringin dissolved in 50% PEG400 Not applicable 746.7 mg/kg bw Single dose 6 9 0.83 2.98 1252.24 Graph FANG 2006
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
rat studies
naringenin Not applicable 270 mg/kg bw Single dose 10 7.94 16.25 7.94 21893.46 Graph MA 2006
naringenin Not applicable 50 mg/kg bw Single dose 6 0.88 µmol after 18 hours 0.05 nmol/mL after 18 hours EL MOHSEN 2004
Rhizoma drynariae Not applicable 70 g/kg bw Single dose 6 8 0.81 1.57 Graph XIAO-HONG LI 2010
dog studies
capsules containing grapefruit extract Food administered
 400 g Single dose 8 20 0 1.78 Graph MATA-BILBAO 2007_02