Showing experiments where 4-Hydroxybenzoic acid has been detected in biofluids Metabolism

  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
5-caffeoylquinic acid Not applicable 2 g/day 7 days 20 29 µmol/24h after 1 weeks OLTHOF 2003
almond skin extract capsules Food administered
 10 capsules Single dose 2 URPI-SARDA 2009_02
black tea solids Food administered
 4 g/day 7 days 20 27 µmol/24h after 1 weeks OLTHOF 2003
citric acid in water Not applicable 0.5 g/day 7 days 20 29 µmol/24h after 1 weeks OLTHOF 2003
cocoa powder in skimmed milk Food administered
Generic food 		40 g/day 4 weeks 42 37.34 µmol after 24 hours 9.73 µmol/L after 24 hours URPI-SARDA 2009_03
cocoa powder in water Food administered
Generic food 		40 g Single dose 21 0.55 nmol/mg creatinine after 24 hours URPI-SARDA 2009_01
cocoa powder in water Food administered
Generic food 		40 g Single dose 21 Graph URPI-SARDA 2010
cocoa powder in whole milk Food administered
Generic food 		40 g Single dose 21 Graph URPI-SARDA 2010
dark chocolate Generic food 80 g Single dose 11 Graph RIOS 2003
quercetin 3-O-rutinoside Not applicable 440 mg/day 7 days 20 29 µmol/24h after 1 weeks OLTHOF 2003
rat studies
5-caffeoylquinic acid Not applicable 250 µmol/day 8 days 8 4 µmol after 8 days GONTHIER 2003_01
caffeic acid Not applicable 250 µmol/day 8 days 8 3.2 µmol after 8 days GONTHIER 2003_01
catechin Not applicable 0.12 g/100 g bw Single dose 8 711.2 µg after 8 days GONTHIER 2003_03
catechin Not applicable 0.1 % of diet 5 days 5 2.1 µmol after 5 days GONTHIER 2003_02
cranberry powder diet Food administered
 6.6 mg/kg bw Single dose 10 7.2 µg/mg creatinine after 30 days PRIOR 2010
natural cocoa Food administered
 10 % of diet 2 weeks 7 10.28 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
natural cocoa powder Food administered
 4.8 g/kg bw/day 2 weeks 7 20.08 nmol/mg creatinine after 14 days URPI-SARDA 2009_01
procyanidin dimer B3 Not applicable 0.1 % of diet 5 days 5 2.9 µmol after 5 days GONTHIER 2003_02
procyanidin polymers Not applicable 0.1 % of diet 5 days 5 1.45 µmol after 5 days GONTHIER 2003_02
procyanidin trimer C2 Not applicable 0.1 % of diet 5 days 5 1.5 µmol after 5 days GONTHIER 2003_02
quinic acid Not applicable 250 µmol/day 8 days 8 3.2 µmol after 8 days GONTHIER 2003_01
red wine and red grape extract capsules Food administered
 1 capsules/day 28 days 26 Detected (unquantified) GRUN 2008
wine powder Food administered
 0.5 g/100 g bw Single dose 8 1073.6 µg after 8 days GONTHIER 2003_03
  Urine Plasma  
[polyphenol] source used in experiment Source composition Doses administered Dose duration Total no. subjects Mean urinary excretion (%) Kinetic data Tmax (hours) Mean Cmax (µmol/L) Half life (hours) AUC (µmol/L·h) Kinetic data Reference
human studies
green tea Food administered
Generic food 		300 mL Single dose 5 Graph ROOWI 2010
orange juice fortified with hesperidin Food administered
 250 mL Single dose 5 Graph ROOWI 2009
orange juice fortified with hesperidin with 150 mL natural yoghurt Food administered
 250 mL Single dose 5 Graph ROOWI 2009
virgin olive oil Food administered
Generic food 		30 mL Single dose 5 Graph SUAREZ 2009
rat studies
cranberry powder diet Food administered
 6.6 mg/kg bw Single dose 10 1.98 µg/mg creatinine after 30 days PRIOR 2010
pelargonidin Not applicable 50 mg/kg bw Single dose 15 155 nmol after 18 hours 0.8 nmol/mL after 2 hours EL MOHSEN 2006
raspberry juice Food administered
Generic food 		2.77 mL Single dose 24 Graph BORGES 2007
wild lowbush blueberry diet Generic food 8 % of diet 8 weeks 8 Graph Graph DEL BO 2010