Showing experiments where Hippuric acid has been detected in biofluids Metabolism
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| 5-caffeoylquinic acid | Not applicable | 2 g/day | 7 days | 20 | 8100 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| black tea solids |
Food administered |
4 g/day | 7 days | 20 | 4400 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| citric acid in water | Not applicable | 0.5 g/day | 7 days | 20 | 2500 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 | 59.43 nmol/mg creatinine after 24 hours | URPI-SARDA 2009_01 | ||||||
| cocoa powder in water |
Food administered Generic food |
40 g | Single dose | 21 |
|
URPI-SARDA 2010 | ||||||
| cocoa powder in whole milk |
Food administered Generic food |
40 g | Single dose | 21 |
|
URPI-SARDA 2010 | ||||||
| dark chocolate | Generic food | 80 g | Single dose | 11 |
|
RIOS 2003 | ||||||
| quercetin 3-O-rutinoside | Not applicable | 440 mg/day | 7 days | 20 | 2700 µmol/24h after 1 weeks | OLTHOF 2003 | ||||||
| rat studies | ||||||||||||
| 5-caffeoylquinic acid | Not applicable | 250 µmol/day | 8 days | 8 | 36.5 |
|
98.2 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| caffeic acid | Not applicable | 250 µmol/day | 8 days | 8 | 22.9 | 428 µmol after 8 days | 54.2 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| catechin | Not applicable | 0.12 g/100 g bw | Single dose | 8 | 70 µmol/L after 8 days | GONTHIER 2003_03 | ||||||
| catechin | Not applicable | 0.1 % of diet | 5 days | 5 | 30.25 µmol after 5 days | GONTHIER 2003_02 | ||||||
| cranberry powder diet |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 218 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| instant coffee powder in water |
Food administered |
4 g | Single dose | 5 | 299.92 mg after 1440 minutes | RECHNER 2001 | ||||||
| natural cocoa |
Food administered |
10 % of diet | 2 weeks | 7 | 75.34 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| natural cocoa powder |
Food administered |
4.8 g/kg bw/day | 2 weeks | 7 | 62.45 nmol/mg creatinine after 14 days | URPI-SARDA 2009_01 | ||||||
| procyanidin dimer B3 | Not applicable | 0.1 % of diet | 5 days | 5 | 33.25 µmol after 5 days | GONTHIER 2003_02 | ||||||
| procyanidin polymers | Not applicable | 0.1 % of diet | 5 days | 5 | 25.5 µmol after 5 days | GONTHIER 2003_02 | ||||||
| procyanidin trimer C2 | Not applicable | 0.1 % of diet | 5 days | 5 | 24.65 µmol after 5 days | GONTHIER 2003_02 | ||||||
| quinic acid | Not applicable | 250 µmol/day | 8 days | 8 | 55.3 | 988.8 µmol after 8 days | 41.1 µmol/L after 8 days | GONTHIER 2003_01 | ||||
| red wine and red grape extract capsules |
Food administered |
1 capsules/day | 28 days | 26 | Detected (unquantified) | GRUN 2008 | ||||||
| wine powder |
Food administered |
0.5 g/100 g bw | Single dose | 8 | 115 µmol/L after 8 days | GONTHIER 2003_03 | ||||||
| Urine | Plasma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [polyphenol] source used in experiment | Source composition | Doses administered | Dose duration | Total no. subjects | Mean urinary excretion (%) | Kinetic data | Tmax (hours) | Mean Cmax (µmol/L) | Half life (hours) | AUC (µmol/L·h) | Kinetic data | Reference |
| human studies | ||||||||||||
| black tea solids in water |
Food administered |
6 g | Single dose | 17 | 3.75 mmol after 4 days | MULDER 2005 | ||||||
| blackcurrant juice |
Food administered |
330 mL | Single dose | 10 | 515.45 mg after 24 hours |
|
RECHNER 2002_02 | |||||
| caffeine in capsules | Not applicable | 360 mg | Single dose | 17 | 1.89 mmol after 4 days | MULDER 2005 | ||||||
| green tea |
Food administered Generic food |
300 mL | Single dose | 5 |
|
ROOWI 2010 | ||||||
| green tea solids in water |
Food administered |
6 g | Single dose | 17 | 4.22 mmol after 4 days | MULDER 2005 | ||||||
| orange juice fortified with hesperidin |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| orange juice fortified with hesperidin with 150 mL natural yoghurt |
Food administered |
250 mL | Single dose | 5 |
|
ROOWI 2009 | ||||||
| rat studies | ||||||||||||
| catechin | Not applicable | 0.2 % of diet | 6 weeks | 8 | Detected (unquantified) | FARDET 2008_01 | ||||||
| cranberry powder diet |
Food administered |
6.6 mg/kg bw | Single dose | 10 | 115 µg/mg creatinine after 30 days | PRIOR 2010 | ||||||
| ferulic acid | Not applicable | 0.42 % of diet | 0 hours | 5 | Detected (unquantified) | FARDET 2008_02 | ||||||
| lignin-enriched wheat bran | Not applicable | 3 % of diet | 0 hours | 5 | Detected (unquantified) | FARDET 2008_02 | ||||||
| poplar wood lignins | Not applicable | 0.42 % of diet | 0 hours | 5 | Detected (unquantified) | FARDET 2008_02 | ||||||
| raspberry juice |
Food administered Generic food |
2.77 mL | Single dose | 24 |
|
BORGES 2007 | ||||||
| sinapic acid | Not applicable | 0.42 % of diet | 0 hours | 5 | Detected (unquantified) | FARDET 2008_02 | ||||||
| wild lowbush blueberry diet | Generic food | 8 % of diet | 8 weeks | 8 |
|
|
DEL BO 2010 | |||||